CHRNB1 Antibody

說(shuō)明書(shū)

中文名稱(chēng)：

CHRNB1兔多克隆抗體
貨號(hào)：

CSB-PA15049A0Rb
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate
All lanes: CHRNB1 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57, 50 kDa
Observed band size: 57 kDa

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA15049A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA15049A0Rb at dilution of 1:100

Immunofluorescent analysis of PC-3 cells using CSB-PA15049A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品描述：

The CHRNB1 polyclonal antibody is an IgG that recognizes and binds specifically to the human CHRNB1 protein. CHRNB1 forms a subunit of the nicotinic acetylcholine receptor (nAChR), which is essential for neurotransmission in the nervous system. Mutations in CHRNB1 protein can lead to impaired neurotransmission and are associated with a range of neurological and neuromuscular disorders such as congenital myasthenic syndrome (CMS).

The CHRNB1 polyclonal antibody is generated from rabbits. The recombinant human acetylcholine receptor subunit beta protein (24-244aa) is used as the immunogen. After protein G purification, this CHRNB1 antibody reaches up to 95% in purity. It is suitable for use in ELISA, WB, IF, and IHC applications.
產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) CHRNB1 Polyclonal antibody
Uniprot No.：

P11230
基因名：

CHRNB1
別名：

Acetylcholine receptor protein beta chain precursor antibody; Acetylcholine receptor subunit beta antibody; ACHB_HUMAN antibody; AChR antibody; ACHRB antibody; Cholinergic receptor nicotinic beta polypeptide 1 (muscle) antibody; Chrnb 1 antibody; CHRNB antibody; chrnb1 antibody; CMS1D antibody; CMS2A antibody; Nicotinic acetylcholine receptor beta subunit precursor antibody; SCCMS antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Acetylcholine receptor subunit beta protein (24-244AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，CHRNB1 Antibody (CSB-PA15049A0Rb)，的標(biāo)記方式是Non-conjugated。對(duì)于CHRNB1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱(chēng)	應(yīng)用
HRP	CSB-PA15049B0Rb	CHRNB1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA15049C0Rb	CHRNB1 Antibody, FITC conjugated
Biotin	CSB-PA15049D0Rb	CHRNB1 Antibody, Biotin conjugated	ELISA

克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
基因功能參考文獻(xiàn)：
1. Study traced the cause of congenital myasthenia syndrome in unrelated patients with dominant missense mutations in the M2 domain of AChR. A valine residue is replaced by a smaller alanine either in the epsilon subunit or an equivalent position in the beta one. Also, each valine in the valine ring was found to contribute to channel kinetics equally, and the valine ring has bee optimized during evolution to govern channe... PMID: 27375219
2. This study reports on the presence of the CHRNB1 at the cellular level in human skeletal muscle and placenta and that mRNA expression mirrors that of protein within cell types. PMID: 28153524
3. These findings identify novel Golgi retention signals in the beta and delta subunit loops that regulate surface trafficking of assembled AChR and may help prevent surface expression of unassembled subunits. PMID: 24240098
4. Single nucleotide polymorphisms , rs55633891 (alpha9, C>T) and rs17856697 (beta1, A>G), did not exhibit a significant trend to be associated with cervical lesions. PMID: 22406075
5. the beta1 subunit showed significantly increased expression in lung tumors as compared to non-tumor bronchial tissue PMID: 17015027
6. Extracellular beta1-beta2 and cysteine-loops bridge the pre-M1 transmembrane domain and M2-M3 linker to transduce agonist binding into channel gating. PMID: 19279256
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相關(guān)疾病：

Myasthenic syndrome, congenital, 2A, slow-channel (CMS2A); Myasthenic syndrome, congenital, 2C, associated with acetylcholine receptor deficiency (CMS2C)
亞細(xì)胞定位：

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Beta-1/CHRNB1 sub-subfamily
數(shù)據(jù)庫(kù)鏈接：

HGNC: 1961

OMIM: 100710

KEGG: hsa:1140

STRING: 9606.ENSP00000304290

UniGene: Hs.330386

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