CHAC1 Antibody

中文名稱：

CHAC1兔多克隆抗體
貨號：

CSB-PA883606LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA883606LA01HU at dilution of 1:100

Immunofluorescence staining of Hela cells with CSB-PA883606LA01HU at 1:260, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CHAC1 Polyclonal antibody
Uniprot No.：

Q9BUX1
基因名：

CHAC1
別名：

Blocks Notch protein antibody; Botch antibody; Cation transport regulator like protein 1 antibody; Cation transport regulator-like protein 1 antibody; ChaC antibody; ChaC cation transport regulator homolog 1 antibody; ChaC cation transport regulator like 1 antibody; chac1 antibody; CHAC1_HUMAN antibody; Gamma GCT acting on glutathione homolog 1 antibody; Gamma-GCG 1 antibody; Glutathione-specific gamma-glutamylcyclotransferase 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Glutathione-specific gamma-glutamylcyclotransferase 1 protein (43-264AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CHAC1 Antibody (CSB-PA883606LA01HU)，的標記方式是Non-conjugated。對于CHAC1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA883606LB01HU	CHAC1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA883606LC01HU	CHAC1 Antibody, FITC conjugated
Biotin	CSB-PA883606LD01HU	CHAC1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
基因功能參考文獻：
1. The data revealed that CHAC2 prevented CHAC1-mediated GSH degradation, which suggests that CHAC2 competes with CHAC1 to maintain GSH homeostasis. PMID: 29054545
2. Temozolomide (TMZ)-mediated gene expression profiles and networks are involved in inducing glioblastoma cell death. Increased CHAC1 and reduced Notch3 levels are both also significantly involved in TMZ-mediated cytotoxicity. The TMZ-regulated CHAC1 pathway inhibits Notch3 activation, resulting in attenuation of Notch3-mediated signaling pathways. PMID: 27986595
3. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element. PMID: 25931127
4. Botch regulates Notch signaling through deglycination and identify a posttranslational modification of Notch that plays an important role in neurogenesis. PMID: 24767995
5. nisin exerts these effects on HNSCC, in part, through CHAC1, a proapoptotic cation transport regulator, and through a concomitant CHAC1-independent influx of extracellular calcium PMID: 23342279
6. High CHAC1 mRNA expression could be an independent indicator for elevated risk of cancer recurrence in breast and ovarian cancer PMID: 22108517
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亞細胞定位：

Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network.
蛋白家族：

Gamma-glutamylcyclotransferase family, ChaC subfamily
數據庫鏈接：

HGNC: 28680

OMIM: 614587

KEGG: hsa:79094

STRING: 9606.ENSP00000398105

UniGene: Hs.155569

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