CGGBP1 Antibody

中文名稱：

CGGBP1兔多克隆抗體
貨號：

CSB-PA890676LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA890676LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA890676LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CGGBP1 Polyclonal antibody
Uniprot No.：

Q9UFW8
基因名：

CGGBP1
別名：

20 kDa CGG binding protein antibody; 20 kDa CGG-binding protein antibody; CGBP1_HUMAN antibody; CGG binding protein 1 antibody; CGG triplet repeat binding protein 1 antibody; CGG triplet repeat-binding protein 1 antibody; CGG-binding protein 1 antibody; CGGBP 1 antibody; CGGBP antibody; Cggbp1 antibody; OTTHUMP00000213853 antibody; OTTHUMP00000213877 antibody; p20 CGG binding protein antibody; p20 CGGBP antibody; p20 CGGBP DNA binding protein antibody; p20-CGGBP DNA-binding protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human CGG triplet repeat-binding protein 1 protein (1-167AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CGGBP1 Antibody (CSB-PA890676LA01HU)，的標記方式是Non-conjugated。對于CGGBP1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA890676LB01HU	CGGBP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA890676LC01HU	CGGBP1 Antibody, FITC conjugated
Biotin	CSB-PA890676LD01HU	CGGBP1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter.
基因功能參考文獻：
1. By studying global gene expression patterns and genome-wide DNA-binding patterns of CGGBP1, it has been shown that a possible mechanism through which it affects the expression of RNA Pol II-transcribed genes in trans depends on Alu RNA. PMID: 25483050
2. CGGBP1 has no direct effect on FMR1 transcription and CGG repeat stability. PMID: 26306647
3. CGGBP1 protein play an important cytoprotective role in patients with cancer. PMID: 26482656
4. CGGBP1 is a possible bidirectional regulator of CpG methylation at Alus, and acts as a repressor of methylation at L1 retrotransposons. PMID: 25981527
5. Our results suggest that CGGBP1 phosphorylation at S164 is a novel telomere protection signal, which can affect telomere-protective function of the shelterin complex PMID: 24196442
6. Over-expression of miR-7 could significantly inhibit the growth of human lung cancer cells in vivo and in vitro, which might be related to the down-regulated expression of tumor growth-associated protein CGGBP1 PMID: 24491049
7. CGGBP1 depletion by RNA interference in tumor-derived cells caused an increase in the cell population at G0/G1 phase and reduced the number of cells in the S phase. PMID: 21733196
8. CGGBP-20 downregulates the activity of 5'-region of FMR1 gene in the presence of GCC-triplets only. PMID: 20141036
9. CGGBP1 was mapped to chromosome 3p and a sequence of 235 nucleotides 5' upstream of CGGBP1 is essential for promoter activity. PMID: 14667814
10. Differences in factors implicated in CGG repeat instability--CGG repeat size, XS548/FRAXAC1 haplotypes, and AGG interspersion pattern-are present in the Basque populations analyzed. PMID: 19728537
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亞細胞定位：

Nucleus.
組織特異性：

Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain.
數據庫鏈接：

HGNC: 1888

OMIM: 603363

KEGG: hsa:8545

STRING: 9606.ENSP00000381428

UniGene: Hs.444818

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