CERS4 Antibody
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中文名稱：CERS4兔多克隆抗體
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貨號：CSB-PA046553
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規格：￥2024
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圖片：
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Western blot analysis of extracts from COLO cells, Jurkat cells and HUVEC cells, using LASS4 antibody. -
Immunohistochemistry analysis of paraffin-embedded human brain tissue using LASS4 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CERS4 Polyclonal antibody
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Uniprot No.：
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基因名：CERS4
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別名：CERS4; LASS4; Ceramide synthase 4; CerS4; LAG1 longevity assurance homolog 4; Sphingosine N-acyltransferase CERS4
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from internal of Human LASS4.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.
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基因功能參考文獻：
- nine SNPs in the ceramide synthase 4 (CERS4) region were associated with circulating C23:0 levels (adjusted P<5x10-2) PMID: 29738550
- These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths. PMID: 26887952
- mRNA level of CerS4 is higher in cancerous cell lines and decreases following the induction of apoptosis. PMID: 25779024
- Co-expression of CerS2 with CerS4/CerS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation. PMID: 23538298
- The linkage and association of phospholipid transfer protein activity to LASS4 were studied. PMID: 21757428
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亞細胞定位：Endoplasmic reticulum membrane; Multi-pass membrane protein.
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數據庫鏈接：
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