CERS3 Antibody, Biotin conjugated
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中文名稱：CERS3兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA811597LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) CERS3 Polyclonal antibody
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Uniprot No.：
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基因名：CERS3
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別名：CERS3; LASS3; Ceramide synthase 3; CerS3; Dihydroceramide synthase 3; LAG1 longevity assurance homolog 3; Sphingosine N-acyltransferase CERS3; Ultra-long-chain ceramide synthase CERS3; Very-long-chain ceramide synthase CERS3
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Ceramide synthase 3 protein (59-134AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.
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基因功能參考文獻(xiàn)：
- Novel mutations in CERS3 co-segregated with the ichthyosis phenotype in six Iranian families. PMID: 28875980
- testis-specific SLs, which we also link to CerS3 in human testis, are quintessential for male fertility. PMID: 26045466
- Our findings demonstrate that synthesis of very long chain ceramides by CerS3 is a crucial early step for the skin barrier formation and link disorders presenting with congenital ichthyosis to defects in sphingolipid metabolism and lipid architecture. PMID: 23549421
- these data present a novel pathway involved in ARCI development and, moreover, provide the first evidence that CERS3 plays an essential role in human sphingolipid metabolism for the maintenance of epidermal lipid homeostasis. PMID: 23754960
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相關(guān)疾病：Ichthyosis, congenital, autosomal recessive 9 (ARCI9)
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亞細(xì)胞定位：Endoplasmic reticulum membrane; Multi-pass membrane protein.
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組織特異性：Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level).
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數(shù)據(jù)庫鏈接：
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