CERKL Antibody

中文名稱：

CERKL兔多克隆抗體
貨號：

CSB-PA669888LA01HU
規格：

￥440
圖片：
Western blot
All lanes: CERKL antibody at 14 μg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 63, 60, 53, 48, 43, 25, 20, 58 kDa
Observed band size: 63 kDa

Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA669888LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA669888LA01HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA669888LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CERKL Polyclonal antibody
Uniprot No.：

Q49MI3
基因名：

CERKL
別名：

Ceramide kinase like protein antibody; Ceramide kinase-like protein antibody; CERKL antibody; CERKL_HUMAN antibody; Retinitis pigmentosa 26 (autosomal recessive) antibody; RP26 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Ceramide kinase-like protein (1-558AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CERKL Antibody (CSB-PA669888LA01HU)，的標記方式是Non-conjugated。對于CERKL Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA669888LB01HU	CERKL Antibody, HRP conjugated	ELISA
FITC	CSB-PA669888LC01HU	CERKL Antibody, FITC conjugated
Biotin	CSB-PA669888LD01HU	CERKL Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.
基因功能參考文獻：
1. Our report indicates that the first diagnostic test for Finnish patients with sporadic or autosomal recessive retinal dystrophy should be a targeted test for founder mutations in the CERKL. PMID: 29068140
2. The initial presenting features of CERKL-related retinopathy are distinct and unusual. Recognition of this initial presenting phenotype can facilitate earlier molecular diagnosis and genetic counseling. PMID: 24547929
3. pVHL interacts with CERKL and ubiquitinates it for oxygen dependent proteasomal degradation. PMID: 26296657
4. CERKL interacts with TRX2 and plays a novel key role in the regulation of the TRX2 antioxidant pathway. PMID: 24735978
5. An unexpected multiplicity of CERKL transcriptional start sites (four in each species) plus a high variety of alternative splicing events primarily affecting the 5' half of the gene generate >20 fully validated mRNA isoforms in human and 23 in mouse. PMID: 21508105
6. Observational study of genetic testing. (HuGE Navigator) PMID: 20801516
7. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
8. Observational study of genetic testing. (HuGE Navigator) PMID: 20591486
9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
10. Observational study of gene-disease association. (HuGE Navigator) PMID: 20677014
11. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
12. Novel mutation in CERKL which encompassed 13 exons is identified in retinitis pigmentosa PMID: 14681825
13. Data suggest a functional link between CERKL, a new ceramide kinase homolog, and its nucleolar localization. PMID: 15708351
14. Identification of a nuclear localization signal that might be responsible for nucleolar retention of CERKL. PMID: 16581028
15. c.238+1G>A is the second reported mutation of CERKL and is a prevalent founder mutation that underlies approximately 33% of autosomal recessive retinal degeneration cases in the Yemenite Jewish population. PMID: 18055789
16. This study presents the first genotype-phenotype correlation for persons carrying p.Arg257ter mutation and provides clues for a characteristic phenotype of these mutations among persons with autosomal recessive cases. PMID: 18515597
17. This is the third reported mutation in CERKL causing retinal degeneration but is the first report to show that a single amino acid change in CERKL, rather than a null mutation, can cause retinal disease. PMID: 18978954
18. Retinitis pigmentosa gene ceramide kinase-like (CERKL) was analyzed to determine CERKL function and contribution to pathogenesis. PMID: 19158957
19. The Pleckstrin Homology (PH) domain of CERK, which is required for Golgi complex localization, can substitute for the N-terminal region of CERKL and allow for wild-type CERKL localization, which is typified by nucleolar accumulation. PMID: 19501188
20. CERKL mutations are associated with widespread retinal degeneration with prominent maculopathy. PMID: 19578027
21. Our data indicate that compound heterozygous mutations of CERKL can cause RP. PMID: 19667359
22. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826
23. Genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18521091
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相關疾病：

Retinitis pigmentosa 26 (RP26)
亞細胞定位：

Cytoplasm. Nucleus, nucleolus. Note=Enriched in nucleoli. May shuttle between nucleus and cytoplasm. Isoform 5 is not enriched in the nucleoli.; [Isoform 2]: Cytoplasm. Nucleus, nucleolus. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum.
組織特異性：

Isoform 1 and isoform 2 are expressed in adult retina, liver and pancreas as well as in fetal brain, lung and kidney. Isoform 3 is expressed in adult retina as well as in fetal lung and liver. Isoform 4 is expressed in adult retina, lung and kidney as wel
數據庫鏈接：

HGNC: 21699

OMIM: 608380

KEGG: hsa:375298

STRING: 9606.ENSP00000341159

UniGene: Hs.732358

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