CEP70 Antibody
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中文名稱：CEP70兔多克隆抗體
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貨號：CSB-PA001585
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規格：￥1090
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圖片：
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Western Blot analysis of COS7 cells using CEP70 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：CEP70
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別名：BITE antibody; Centrosomal protein of 70 kDa antibody; Cep70 antibody; CEP70_HUMAN antibody; p10 binding protein antibody; p10-binding protein antibody
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宿主：Rabbit
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反應種屬：Human,Monkey
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免疫原：Synthesized peptide derived from the Internal region of Human CEP70.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
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基因功能參考文獻：
- Cep70 interacts with tubulin, and promotes the ability of paclitaxel to stimulate microtubule assembly. These data demonstrate that Cep70 mediates paclitaxel sensitivity in breast cancer. PMID: 28632150
- these results demonstrate a critical role for Cep70 in the development and progression of breast cancer. PMID: 28063737
- Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization PMID: 26893288
- findings suggest that Cep70 promotes microtubule stability by interaction with HDAC6 and regulation of tubulin acetylation PMID: 26112604
- data showed that Cep70 increased the microtubule length without affecting the microtubule number in the purified system; results demonstrate that Cep70 could directly regulate microtubule assembly by promoting microtubule elongation instead of microtubule nucleation PMID: 22427462
- These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with gamma-tubulin and underscore its critical role in the regulation of mitotic spindle assembly. PMID: 21795687
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亞細胞定位：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.
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數據庫鏈接：
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