CEP192 Antibody

說(shuō)明書

中文名稱：

CEP192兔多克隆抗體
貨號(hào)：

CSB-PA851560LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA851560LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA851560LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CEP192 Polyclonal antibody
Uniprot No.：

Q8TEP8
基因名：

CEP192
別名：

CEP192 antibody; KIAA1569 antibody; PP8407Centrosomal protein of 192 kDa antibody; Cep192 antibody; Cep192/SPD-2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Centrosomal protein of 192 kDa protein (447-711AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，CEP192 Antibody (CSB-PA851560LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于CEP192 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA851560LB01HU	CEP192 Antibody, HRP conjugated	ELISA
FITC	CSB-PA851560LC01HU	CEP192 Antibody, FITC conjugated
Biotin	CSB-PA851560LD01HU	CEP192 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Required for mitotic centrosome maturation and bipolar spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication. Centrosome-specific activating scaffold for AURKA and PLK1.
基因功能參考文獻(xiàn)：
1. Study shows that the interaction between Cep295 and Cep192 seems to be crucial for the integrity of centriole structure and also for daughter-to-mother centriole conversion. PMID: 27562453
2. Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif. PMID: 28188792
3. Interphase cells depleted of Cep192 display significantly higher levels of centrosome-associated Pericentrin while overexpression of Cep192 reduces the levels of centrosomal Pericentrin. PMID: 24971877
4. Plk1 promotes centrosome-based bipolar spindle formation by forming two functionally nonredundant complexes with Cep192. PMID: 26012549
5. Study identifies a Cep192-organized signaling cascade that underlies both centrosome maturation and bipolar spindle assembly. PMID: 25042804
6. Plk4 is intricately regulated in time and space through ordered interactions with two distinct scaffolds, Cep192 and Cep152, and a failure in this process may lead to human cancer. PMID: 24997597
7. Loss of the Cep192- or Cep152-dependent interaction with Plk4 resulted in impaired centriole duplication that led to delayed cell proliferation. PMID: 24277814
8. cooperation between Cep192 and Cep152 is crucial for centriole recruitment of Plk4 and centriole duplication during the cell cycle. PMID: 23641073
9. By modulating Cep192 levels, PHD1 thereby affects the processes of centriole duplication and centrosome maturation and contributes to the regulation of cell-cycle progression. PMID: 23932902
10. CEP192 promotes robust mitotic spindle assembly by regulating K63-polyubiquitin-mediated signaling through CYLD. PMID: 22895009
11. Cep192-mediated mechanism maximizes AurA activity at centrosomes and appears essential for the function of these organelles as primary microtubule -organizing centers. PMID: 21097701
12. Cep192 stimulates the formation of the scaffolding upon which gamma-tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis. PMID: 17980596
13. major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells PMID: 18207742
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亞細(xì)胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Pericentriolar location in mitotic centrosomes.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 25515

OMIM: 616426

KEGG: hsa:55125

STRING: 9606.ENSP00000427550

UniGene: Hs.100914

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