CENPH Antibody

說明書

中文名稱：

CENPH兔多克隆抗體
貨號：

CSB-PA278241
規格：

￥1100
圖片：
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA278241(CENPH Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9H3R5
基因名：

CENPH
別名：

CENP H antibody; CENP-H antibody; CENPH antibody; CENPH_HUMAN antibody; Centromere protein H antibody; ICEN35 antibody; Interphase centromere complex protein 35 antibody; Kinetochore protein CENP H antibody; NNF1 antibody; NNF1; MIND kinetochore complex component; homolog antibody; PMF1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human CENPH
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
基因功能參考文獻：
1. In summary, CENP-H may be involved in cell proliferation and apoptosis of hepatocellular carcinoma (HCC)cells through the mitochondrial apoptotic pathway. Combined with previous studies, the data provide a new perspective on HCC development and progression. PMID: 28498417
2. Upregulation of centromere protein H is associated with progression of renal cell carcinoma PMID: 26248586
3. propose that CSPP1 cooperates with CENP-H on kinetochores to serve as a novel regulator of kinetochore microtubule dynamics for accurate chromosome segregation PMID: 26378239
4. CENP-H was overexpressed in HCC, and its level of upregulation was an independent prognostic indicator, suggesting that CENP-H may be an effective therapeutic strategy for the treatment of HCC. PMID: 23970101
5. CENP-H promotes the proliferation of human gastric cancer cells PMID: 22381774
6. High expression of CENP-H in gastric cancer indicates poor prognosis and Survivin may mediate its procancer role. PMID: 22999412
7. Breast cancer patients with high CENP-H expression had short overall survival. CENP-H expression was related with clinical stage. PMID: 21880184
8. upregulated CENP-H and Ki67 levels are significantly associated with short relapse-free survival in hypopharyngeal squamous cell carcinoma (HSSC); these factors may be predictors of a relapsing phenotype in HSSC cases PMID: 22631655
9. Sp1 and Sp3 bind to the CENPH minimal promoter and function as a regulator of the transcription of CENPH in nasopharyngeal carcinomas. PMID: 22682030
10. CENP-H is up-regulated and plays an important role in the aneuploidy frequently observed in colorectal cancers. PMID: 15930286
11. The CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres. PMID: 16622420
12. has an important impact on the architecture and function of the human kinetochore complex PMID: 16875666
13. CENP-H has a role in preventing progression of nasopharyngeal carcinoma PMID: 17255272
14. CENP-C and CENP-H co-localize to the CENP-A chromatin domain. PMID: 17651496
15. CENP-H protein has a role in esophageal carcinoma progression PMID: 18700042
16. expression of CENPH was much higher in cancer cell lines & lung cancer tissue than normal cells & adjacent noncancerous lung tissues; results show that high CENPH protein expression was related to poor outcome in patients with nonsmall cell lung cancer PMID: 19170237
17. TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H. PMID: 19232519
18. Upregulation of CENP-H in tongue cancer is associated with disease progression. PMID: 19500341
19. CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1. PMID: 19625449
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亞細胞定位：

Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.
蛋白家族：

CENP-H/MCM16 family
數據庫鏈接：

HGNC: 17268

OMIM: 605607

KEGG: hsa:64946

STRING: 9606.ENSP00000283006

UniGene: Hs.631967

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