CELSR1 Antibody

中文名稱：

CELSR1兔多克隆抗體
貨號：

CSB-PA868360NA01HU
規格：

￥440
圖片：
IHC image of CSB-PA868360NA01HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CELSR1 Polyclonal antibody
Uniprot No.：

Q9NYQ6
基因名：

CELSR1
別名：

CELSR1 antibody; CDHF9 antibody; FMI2Cadherin EGF LAG seven-pass G-type receptor 1 antibody; Cadherin family member 9 antibody; Flamingo homolog 2 antibody; hFmi2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Peptide sequence from Human Cadherin EGF LAG seven-pass G-type receptor 1 protein (345-363AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CELSR1 Antibody (CSB-PA868360NA01HU)，的標記方式是Non-conjugated。對于CELSR1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA868360NB01HU	CELSR1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA868360NC01HU	CELSR1 Antibody, FITC conjugated
Biotin	CSB-PA868360ND01HU	CELSR1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor that may have an important role in cell/cell signaling during nervous system formation.
基因功能參考文獻：
1. Patients with CELSR1 mutations and spina bifida can have significant renal malformations. PMID: 27597235
2. This single-nucleotide polymorphism-by-sex genome-wide association analysis identified the fetal lung development gene, CELSR1, as a potential sex-specific risk factor for Chronic obstructive pulmonary disease. PMID: 27854507
3. Upregulating CELSR1 expression significantly promoted cell growth, while knocking down CELSR1 inhibited the growth and decreased tube formation. PMID: 27301287
4. Single nucleotide polymorphisms in nNOS, renalase, MTHFR, CELSR1 and XYLB genes were found significantly associated with ischemic stroke in Chinese patients. PMID: 25855559
5. the present study has proven for the first time that CELSR1 is a susceptibility gene for ischaemic stroke in the Chinese Han population, especially for large artery atherosclerosis. PMID: 25117632
6. CELSR1 mutations contribute to the risk of spina bifida in a cohort of spina bifida patients from California PMID: 24632739
7. Celsr1 regulates dynamic cell movements by inhibiting stabilization of VE-cadherin and maturation of adherens junctions. PMID: 23792146
8. CELSR1 is a risk factor for neural tube defects or caudal agenesis via pathogenic role of planar cell polarity signaling in these malformations. PMID: 22371354
9. Missense variants in CELSR1 may represent a cause of craniorachischisis in humans, as in mice, with defective planar cell polarity protein trafficking to the plasma membrane a likely pathogenic mechanism. PMID: 22095531
10. CELSR1 may have a role in ischemic stroke, as shown in a Portuguese case-control cohort PMID: 21511255
11. The planar cell polarity genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. PMID: 20223754
12. Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. PMID: 19403135
13. exclusion as a candidate gene for schizophrenia-- a cadhrin gene PMID: 11807409
14. Variations in the nine ectodomains of CELSR1 do not increase susceptibility to schizophrenia. PMID: 12782967
顯示更多

收起更多
相關疾病：

Neural tube defects (NTD)
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 2 family, LN-TM7 subfamily
數據庫鏈接：

HGNC: 1850

OMIM: 182940

KEGG: hsa:9620

STRING: 9606.ENSP00000262738

UniGene: Hs.252387

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human