CELF2 Antibody

說明書

中文名稱：

CELF2兔多克隆抗體
貨號：

CSB-PA006217GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O95319
基因名：

CELF2
別名：

Bruno-like protein 3 antibody; BRUNOL3 antibody; Cardiac elav type RNA binding protein antibody; CELF-2 antibody; celf2 antibody; CELF2_HUMAN antibody; CUG BP2 antibody; CUG triplet repeat RNA-binding protein 2 antibody; CUG-BP- and ETR-3-like factor 2 antibody; CUG-BP2 antibody; CUGBP Elav like family member 2 antibody; CUGBP Elav-like family member 2 antibody; CUGBP2 antibody; dJ323N1.1 antibody; elav type RNA binding protein antibody; ELAV-type RNA-binding protein 3 antibody; ETR 3 antibody; ETR-3 antibody; ETR3 antibody; HGNC:2550 antibody; hNAPOR antibody; NAPOR 2 antibody; NAPOR antibody; Neuroblastoma apoptosis-related RNA-binding protein antibody; Neuroplastoma apoptosis related RNA binding protein 3 antibody; RNA binding protein BRUNOL3 antibody; RNA-binding protein BRUNOL-3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human CUGBP2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA.
基因功能參考文獻：
1. Overexpression of CELF2 could reverse miR-615-3p's oncogenic functions. PMID: 29501762
2. CUG-BP2 binds to AU-rich motifs found in the COX-2 mRNA 3'-UTR. PMID: 28935965
3. Study provides evidence for a generalized position- dependent activity of CELF2 in splicing that can be used to predict its consequence on alternative splicing in a cell-type independent manner. PMID: 27096301
4. These data suggest an interplay between CELF2 and hnRNP C as the mechanistic basis for activation-dependent alternative splicing of TRAF3 exon 8. PMID: 28031331
5. Haplotype-dependent allele-specific methylation of CELF2 gene is associated with neurological disorders. PMID: 27153397
6. CUGBP2 expression at the messenger RNA (mRNA) level was 2.2-fold lower and could be associated with high chemoresistance and early dissemination of pancreatic cancer. PMID: 26691217
7. the genetic variant rs3740194 in CELF2 gene might be a valuable predictor for NPC prognosis PMID: 26314850
8. Data show miR95 expression level positively related to glioma grade and its downregulation affects proliferation, invasion and apoptosis by targeting CELF2. MiR95 is identified as a putative therapeutic target and CELF2 as a potential tumor suppressor. PMID: 26165303
9. a widespread role for the JNK-CELF2 axis in controlling splicing during T-cell activation, including a specific role in propagating JNK signaling. PMID: 26443849
10. The A allele of rs2242451 in CUGBP2 might decrease Alzheimer disease risk in the Chinese Han population. PMID: 25801238
11. novel mechanisms for CELF2 regulation that may broadly impact CELF2 expression across diverse cell types. PMID: 25870297
12. There was evidence of association for recently-reported late-onset Alzheimer's disease risk loci, including BIN1 and CLU and CUGBP2 with APOE. PMID: 21379329
13. Alternative splicing of LEF1 exon 6 is regulated during pre-TCR signaling in thymic development and in response to activation of the JSL1 T-cell line and this is driven by the activity of CELF2. PMID: 21444716
14. results indicate the occurrence of a mis-splicing event in myotonic dystrophy type 1 that is induced neither by a loss of muscleblind-like 1 (MBNL1) function nor by a gain of CUGBP1 PMID: 21439371
15. BRUNOL3 appears to be an important factor for thymus development and is therefore a candidate gene for the thymus hypoplasia/aplasia seen in partial monosomy 10p patients. PMID: 12110949
16. Determination of ETR-3 protein domains required for RNA splicing. PMID: 14973222
17. data suggest that CUGBP2 is a critical regulator of the apoptotic response to genotoxic injury in breast cancer cells PMID: 15033780
18. Lipopolysaccharide inhibition of CUGBP2 is a prostaglandin-dependent mechanism. PMID: 15358864
19. Developmental upregulation of apoB mRNA editing from approximately 3% to 88% begins with decreased levels of inhibitory CUG binding protein 2 (CUGBP2) expression. PMID: 16920700
20. CUGBP2 overrides HuR and suppresses COX-2 mRNA translation. PMID: 17383427
21. Data demonstrate that cells expressing CUGBP2 variant 1 undergo apoptosis during mitosis, suggesting mitotic catastrophe. PMID: 18258790
22. Demonstrate that CUGBP2 inhibits Mcl-1 expression by inhibiting Mcl-1 mRNA translation, resulting in driving the cells to apoptosis during the G(2) phase of the cell cycle. PMID: 18292181
23. Data demonstrate that PGE(2) protects colon cancer cells from ionizing radiation-induced mitotic catastrophe in part through suppression of CUGBP2 expression. PMID: 18325984
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

CELF/BRUNOL family
組織特異性：

Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas.
數據庫鏈接：

HGNC: 2550

OMIM: 602538

KEGG: hsa:10659

STRING: 9606.ENSP00000389951

UniGene: Hs.309288

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