CDNF Antibody

說明書

中文名稱：

CDNF兔多克隆抗體
貨號：

CSB-PA396777
規格：

￥1090
圖片：
Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q49AH0
基因名：

CDNF
別名：

Arginine rich mutated in early stage tumors like 1 antibody; ARMET L1 antibody; ARMET like protein 1 antibody; ARMET-like protein 1 antibody; ARMETL 1 antibody; ARMETL1 antibody; CDNF antibody; CDNF_HUMAN antibody; Cerebral dopamine neurotrophic factor antibody; Conserved dopamine neurotrophic factor antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide from Human protein at AA range: 31-80
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC,ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	IHC-p:1:50-300
ELISA	1:10000-20000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.
基因功能參考文獻：
1. Polymorphisms in CDN,F identified in a Han Chinese population, were associated with increased susceptibility to schizophrenia. PMID: 29298719
2. In various animal models of Parkinson Disease, CDNF is efficient in protecting and repairing dopaminergic neurons, and it inhibits endoplasmic reticulum stress, euroinflammation, and apoptosis. PMID: 28337696
3. The results showed that AAV8-CDNF administration significantly improved the motor function and increased the tyrosine hydroxylase (TH) levels in Parkinson's disease rats with mild lesions (2 weeks post lesion), but it had limited therapeutic effects in rats with severe lesions (5 weeks post lesion). PMID: 28622392
4. Results suggest that CDNF treatment selectively enhances long-term memory consolidation PMID: 25975173
5. showed that CDNF was able to protect dopaminergic neurons against injury caused by alpha-synuclein oligomers. This advises its use against physiological damages caused by alpha-synuclein oligomers PMID: 26149686
6. Expression of CDNF in the substantia nigra has an anti-inflammatory effect on experimental Parkinson's disease. PMID: 25511018
7. Although no CDNF mutations are found in early-onset Parkinson's disease patient samples, a trend towards increased risk for Parkinson's in carriers of the C allele of rs7094179 single nucleotide polymorphism (SNP) is found. PMID: 21320571
8. expressed in several tissues; might be beneficial for the treatment of Parkinson's disease PMID: 17611540
9. structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain PMID: 19258449
10. Study suggests that there is no association between variants in the CDNF gene and cocaine dependence. PMID: 19429035
11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19429035
顯示更多

收起更多
亞細胞定位：

Secreted.
蛋白家族：

ARMET family
組織特異性：

Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
數據庫鏈接：

HGNC: 24913

OMIM: 611233

KEGG: hsa:441549

STRING: 9606.ENSP00000419395

UniGene: Hs.559067

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
VIM Recombinant Monoclonal Antibody

Applications: ELISA, IHC, IF

Species Reactivity: Human
VDR Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human