CDKN2D Antibody

說明書

中文名稱：

CDKN2D兔多克隆抗體
貨號：

CSB-PA006485
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P55273
基因名：

CDKN2D
別名：

CDKN2DCyclin-dependent kinase 4 inhibitor D antibody; p19-INK4d antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human p19.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:40000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Interacts strongly with CDK4 and CDK6 and inhibits them.
基因功能參考文獻：
1. p19(INK4d) plays an active role during human tooth development along with MSX1 and MSX2 PMID: 28933666
2. We unexpectedly found that p19INK4d plays an important role in human terminal erythropoiesis PMID: 27879259
3. p19(INK4D) is one of the key mediators of miR-125b activity during the onset of megakaryocyte polyploidization. PMID: 27763644
4. p19 may play an important role in the ototoxic effects of cisplatin and is probably involved in the pathogenesis of hearing loss. PMID: 26722409
5. MiR-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D and MAP3K1 expression. PMID: 26019450
6. Data indicate that upon oxidative DNA damage, cyclin-dependent kinase inhibitor p19INK4d strongly binds to and relaxes chromatin. PMID: 25204969
7. CDKN2D repression by PML/RARalpha disrupts both cell proliferation and differentiation in the pathogenesis of acute promyelocytic leukemia. PMID: 25275592
8. p19-INK4d inhibits neuroblastoma cell growth, induces differentiation and is hypermethylated and downregulated in MYCN-amplified neuroblastomas. PMID: 25104850
9. CDKN2D-WDFY2 fusion could be an important molecular signature for understanding and classifying sub-lineages among heterogeneous high-grade serous ovarian carcinomas. PMID: 24675677
10. Mutations in CDKN2D is associated with sporadic parathyroid adenoma. PMID: 24127162
11. P19(INK4d) expression is a poor prognostic factor in ovarian cancer patients. PMID: 24022213
12. PTB plays as a negative regulator in H1299 cell proliferation at least by inducing p19(Ink4d) expression at transcriptional and post-transcriptional levels. PMID: 23536791
13. Up-regulation of CDKN2D during in-vitro passages of human amniotic fluid-derived mesenchymal stromal cells may indicate the begging of early senescence process in a p53-independent mechanism. PMID: 22747700
14. E2F1 is involved in the induction of p19INK4d following UV irradiation PMID: 22476863
15. CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response to ensure cell survival. PMID: 22558186
16. expression of p19INK4D may be an effective predictor of clinical behavior in hepatocellular carcinoma, and therefore, a new prognostic marker PMID: 21901251
17. p19INK4d is transcriptionally regulated by E2F1 through two response elements present in the p19INK4d promoter. PMID: 21765927
18. protein folding and stability PMID: 11786024
19. The human p19(INK4d) gene is under the control of TATA-less promoter and the Sp1 binding site is involved in the transcription. PMID: 12062451
20. Deletions in the CDKN2D locus and hypermethylation in the CDKN2D promoter region plays a role in ovarian granulosa cell tumorogenesis. PMID: 12203782
21. p19(INK4d) in addition to p21(WAF1/Cip1) is an important molecular target of HDAC inhibitors inducing growth arrest PMID: 15107822
22. In addition to its role as cell cycle inhibitor, p19INK4d is involved in maintenance of DNA integrity and, therefore, would contribute to cancer prevention. PMID: 15750620
23. Data suggest that the graded stability and the facile unfolding of repeats 1 and 2 is a prerequisite for the down-regulation of the inhibitory activity of p19(INK4d) during the cell-cycle. PMID: 17804013
24. The study shows that mimicking the phosphorylation site of p19INK4d by a glutamate substitution at position 76 dramatically decreases the stability of the native but not an intermediate state. PMID: 19063602
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

CDKN2 cyclin-dependent kinase inhibitor family
數據庫鏈接：

HGNC: 1790

OMIM: 600927

KEGG: hsa:1032

STRING: 9606.ENSP00000337056

UniGene: Hs.435051

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