CDKN2AIP Antibody
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中文名稱：CDKN2AIP兔多克隆抗體
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貨號：CSB-PA005090GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：CDKN2AIP
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別名：Calcium response factor antibody; CARF antibody; CARF_HUMAN antibody; CDKN2A interacting protein antibody; CDKN2A-interacting protein antibody; Cdkn2aip antibody; collaborates/cooperates with ARF (alternate reading frame) protein antibody; Collaborator of ARF antibody; FLJ20036 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human CDKN2AIP
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.
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基因功能參考文獻：
- a comprehensive current understanding into the molecular mechanisms of CARF functions in regulation of DNA damage response, cell cycle checkpoints, cell survival and death signaling pathways. PMID: 28754531
- report that CARF (Collaborator of ARF) is a new target of miR-335 that regulates its growth suppressor function by complex crosstalk with other proteins including p16(INK4A), pRB, HDM2 and p21(WAF1) PMID: 27457128
- Oncogenic functions of CARF in hepatocellular carcinoma tumorigenesis is a result of activation of beta-catenin/TCF signaling. PMID: 27829235
- CARF promotes carcinogenesis in p53-deficient cells by repressing p21WAF1 and promoting cell cycle progression. PMID: 26278998
- The results suggest that CARF regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 between the nucleoplasm and nucleolus. PMID: 26531822
- CARF regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. PMID: 24825908
- Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. PMID: 22552337
- CARF knockdown elicited DNA damage response as evidenced by increased levels of phosphorylated ATM and gammaH2AX, leading to induction of mitotic arrest and eventual apoptosis. PMID: 21052095
- CARF may act as a novel key regulator of the p53 pathway at multiple checkpoints PMID: 18555516
- cooperates with human p14ARF in activating p53 PMID: 12154087
- CARF may exert a vital control on p53-HDM2-p21(WAF1) pathway that is central to the cell cycle control, senescence, and DNA damage response of human cells PMID: 17460193
- CARF exerts a vital control on the p53-HDM2-p21WAF1 pathway that is frequently altered in cancer cells. PMID: 18292944
- CARF plays a dual role in regulating p53-mediated senescence and apoptosis, the two major tumor suppressor mechanisms. PMID: 19001376
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亞細胞定位：Nucleus, nucleoplasm.
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蛋白家族：CARF family
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組織特異性：Ubiquitously expressed.
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數據庫鏈接：
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