CDK11B Antibody
-
中文名稱：CDK11B兔多克隆抗體
-
貨號：CSB-PA093758
-
規格：￥2024
-
圖片：
-
Western blot analysis of extracts from HepG2 cells and HUVEC cells, using CD2L1 antibody.
-
-
其他：
產品詳情
-
產品名稱：Rabbit anti-Homo sapiens (Human) CDK11B Polyclonal antibody
-
Uniprot No.：
-
基因名：CDK11B
-
宿主：Rabbit
-
反應種屬：Human,Mouse
-
免疫原：Synthesized peptide derived from N-terminal of Human CD2L1.
-
免疫原種屬：Homo sapiens (Human)
-
克隆類型：Polyclonal
-
純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
濃度：It differs from different batches. Please contact us to confirm it.
-
產品提供形式：Liquid
-
應用范圍：ELISA,WB
-
推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
-
基因功能參考文獻：
- These findings suggest that CDK11 is involved in the regulation of AR pathway and AR can be a potential novel prognostic marker and therapeutic target for osteosarcoma treatment. PMID: 28262798
- DNA methylation exists in the CDC2L1 gene promoter region in keloid tissue fibroblasts. DNA methylation of the CDC2L1 gene promoter region dramatically inhibits the expression of CDK11p58 protein in keloid tissues. PMID: 29204684
- CDK11 has a role in human cancers [review] PMID: 27049727
- we showed high expression of CDK11 in metastatic and recurrent ovarian cancer and demonstrated that CDK11 is essential for ovarian cancer cell growth and survival in vitro and in vivo. PMID: 27207777
- CDK11 was found associated with the TREX/THOC, which recruited this kinase to DNA. Once at the viral genome, CDK11 phosphorylated serines at position 2 in the CTD of RNAPII, which increased levels of cleavage and polyadenylation factors at the HIV 3' end. In its absence, cleavage of viral transcripts was greatly attenuated. PMID: 26567509
- Real-time PCR and dual-luciferase assay showed CDK11(p58) inhibited the mRNA levels of VEGF and the promoter activity of VEGF PMID: 26470709
- Hepsin suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR expression and eIF-2alpha phosphorylation. PMID: 25576733
- CDK11 and CK2 expression are individually essential for breast cancer cell survival, including TNBC. PMID: 25837326
- CDK11(p58) kinase activity appears to be involved in early events in the establishment of the centromere protection machinery. PMID: 24436071
- Data indicate that CDK11p58 is an anti-metastatic gene in ERalpha-positive breast cancer and that the regulation of integrin beta3 by CDK11p58 via the repression of ERalpha signaling may constitute part of a signaling pathway underlying breast cancer invasion. PMID: 25106495
- silencing induces cell death in osteosarcoma PMID: 25348612
- CHK2 kinase constitutively phosphorylates CDK11(p110) in a DNA damage-independent manner. PMID: 23178491
- CDK11 is critical for the growth and proliferation of liposarcoma cells. PMID: 24007862
- CDK11 signaling is essential in osteosarcoma cell growth and survival, further elucidating the regulatory mechanisms controlling the expression of CDK11 and ultimately develop a CDK11 inhibitor that may provide therapeutic benefit against osteosarcoma. PMID: 22791884
- We have identified a correlation between two exon 7 mutations of the CDC2L1 gene and keloid disease. PMID: 22188294
- Since PITSLRE/CDK11 regulates autophagy in both Drosophila and human cells, this kinase represents a novel phylogenetically conserved component of the autophagy machinery. PMID: 21808150
- These data suggest that CDK11 may play a vital role in cell cycle re-entry in Alzheimer disease neurons in an APP-dependent manner. PMID: 21461981
- CDK11(p58), which accumulates only in the vicinity of mitotic centrosomes, directly interacts with the centriole-associated protein kinase Plk4 that regulates centriole number in cells. PMID: 21297952
- Taken together, these results provide evidence for the novel role of CDK11p46 in the regulation of translation and cell apoptosis. PMID: 21371428
- Thr-370 is responsible for the autophosphorylation, dimerization, and kinase activity of CDK11(p58). Moreover, Thr-370 mutants might affect CDK11(p58)-mediated signaling pathways. PMID: 21078675
- interaction with cyclin D3 PMID: 12082095
- CDK11p110 and casein kinase 2 negatively regulate tyrosine hydroxylase[TH] catecholamine biosynthetic activity since phosphoserine 19 of TH requires 14-3-3 binding for optimal enzyme activity and a decreased rate of dephosphorylation PMID: 14675149
- the PITSLRE IRES interacts with the Unr protein, which is more prominently expressed at the G2/M stage of the cell cycle PMID: 15330758
- Although hCDK11 has nearly 80% amino acid sequence identity to hCDK8, siRNA-knockdown study revealed that hCDK8 and hCDK11 possess opposing functions in viral activator VP16-dependent transcriptional regulation. PMID: 18651850
- CDK11(p58) is involved in the negative regulation of VDR. PMID: 19538938
- eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11). PMID: 19854136
顯示更多
收起更多
-
亞細胞定位：Cytoplasm. Nucleus.
-
蛋白家族：Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
-
組織特異性：Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
-
數據庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
