CDK11A Antibody
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中文名稱：CDK11A兔多克隆抗體
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貨號：CSB-PA05204A0Rb
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規(guī)格：￥440
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圖片：
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Western Blot
Positive WB detected in: PC-3 whole cell lysate, Rat kidney tissue
All lanes: CDK11A antibody at 4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 92, 91, 46, 19, 63, 50 kDa
Observed band size: 92 kDa -
IHC image of CSB-PA05204A0Rb diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. -
Immunofluorescent analysis of Hela cells using CSB-PA05204A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) CDK11A Polyclonal antibody
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Uniprot No.：
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基因名：CDK11A
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別名：CD11A_HUMAN antibody; CDC2L2 antibody; CDC2L3 antibody; CDK11 antibody; CDK11 p110 antibody; CDK11 p46 antibody; CDK11 p58 antibody; CDK11A antibody; Cell division cycle 2 like 2 (PITSLRE proteins) antibody; Cell division cycle 2-like protein kinase 2 antibody; Cell division protein kinase 11A antibody; Cyclin-dependent kinase 11A antibody; Galactosyltransferase-associated protein kinase p58/GTA antibody; p58GTA antibody; PITSLRE antibody; PITSLRE B antibody; PITSLRE protein kinase beta antibody; PITSLRE serine/threonine-protein kinase CDC2L2 antibody; PITSLREB antibody
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宿主：Rabbit
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反應(yīng)種屬：Human, Rat
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免疫原：Recombinant Human Cyclin-dependent kinase 11A protein (5-216AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產(chǎn)品，CDK11A Antibody (CSB-PA05204A0Rb)，的標記方式是Non-conjugated。對于CDK11A Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:500-1:1000 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
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基因功能參考文獻：
- CDK11 has a role in human cancers [review] PMID: 27049727
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20508983
- demonstrates that CDK11(p46) directly interacts with RanBPM in vitro and in human cells PMID: 14511641
- the PITSLRE IRES interacts with the Unr protein, which is more prominently expressed at the G2/M stage of the cell cycle PMID: 15330758
- CDK11 kinases could be regulated by interaction with 14-3-3 proteins during cell cycle and apoptosis PMID: 15883043
- CDK11(p58) is a new interacting protein and a novel regulator of histone acetyltransferase (HAT) HBO1. PMID: 15963510
- CDK11p60 can contribute to apoptosis by direct signalling at the mitochondria, thereby amplifying Fas-induced apoptosis in melanoma cells. PMID: 16004605
- These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity. PMID: 16039607
- mitotic CDK11(p58) isoform, but not the CDK11(p110) isoform, associates with mitotic centrosomes PMID: 16462731
- CDC2L2 gene may contribute to the susceptibility of type 2 diabetes in the northern Han Chinese population. PMID: 17177267
- findings show that, in addition to playing a role in spindle formation and structure, CDK11(p58) is also required for sister chromatid cohesion and the completion of mitosis PMID: 17606997
- These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells. PMID: 19122208
- Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis. PMID: 19245811
- study identified p21 activated kinase 1 (PAK1) as a new CDK11(p58) substrate; mapped a new phosphorylation site of Ser174 on PAK1; results indicated PAK1 may serve as a downstream effector of CDK11(p58) during mitosis progression PMID: 19520772
- Observational study of gene-disease association. (HuGE Navigator) PMID: 17177267
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亞細胞定位：Cytoplasm. Nucleus.
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蛋白家族：Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
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組織特異性：Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
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數(shù)據(jù)庫鏈接：
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