CDH4 Antibody
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中文名稱：CDH4兔多克隆抗體
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貨號：CSB-PA829088
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規格：￥1100
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圖片：
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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse heart tissue, A172 cells, 231 cells, Primary antibody: CSB-PA829088(CDH4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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其他：
產品詳情
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Uniprot No.：
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基因名：CDH4
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別名：CDH4; Cadherin-4; Retinal cadherin; R-CAD; R-cadherin
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide of Human CDH4
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
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基因功能參考文獻：
- Low expression of CDH4 is associated with lung cancer. PMID: 28095912
- Further knockdown R-cadherin in linc-cdh4-2 stably overexpressed cells, could significantly upregulate the protein levels of RAC1 and improve the cell migration and invasion abilities. Taken together, the novel linc-cdh4-2 may negatively regulate the motility of the HCC cells through targeting R-cadherin-RAC1 signaling pathway. PMID: 27765630
- Data show that low expression of R-cadherin is associated with the poor prognosis in gastric cancer. PMID: 27029387
- P-cadherin expression correlated with tumor progression and could be an independent predictor for bladder cancer survival. PMID: 24429027
- R-cadherin adherens junction formation facilitates a mesenchymal to epithelial-like transition in MDA-MB-231 cells. PMID: 22820501
- Findings identify an important role of CHD4 in controlling homologous recombination repair to maintain genome stability and establish the potential therapeutic implications of targeting CHD4 deficiency in tumors. PMID: 22219182
- a novel putative tumor suppressor gene that can be frequently and tumor-specifically inactivated by its promoter methylation in nasopharyngeal carcinoma PMID: 21665361
- R-cadherin induces cell motility when expressed in epithelial cells, and this increased motility is dependent upon Rho GTPase activity. PMID: 15143071
- CDH4 may act as a tumor suppressor gene in human gastrointestinal tumors and can potentially be used as an early diagnostic marker for gastrointestinal tumorigenesis PMID: 15548679
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.
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組織特異性：Expressed mainly in brain but also found in other tissues.
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數據庫鏈接：
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