CDCA7L Antibody, FITC conjugated
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中文名稱：CDCA7L兔多克隆抗體, FITC偶聯(lián)
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貨號(hào)：CSB-PA850301LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) CDCA7L Polyclonal antibody
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Uniprot No.：
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基因名：CDCA7L
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別名：c Myc Interacting protein JPO2 antibody; CDA7L_HUMAN antibody; Cdca7l antibody; Cell division cycle-associated 7-like protein antibody; DKFZp762L0311 antibody; HR1 antibody; JPO2 antibody; Protein JPO2 antibody; R1 antibody; RAM2 antibody; Transcription factor RAM2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Cell division cycle-associated 7-like protein (14-167AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
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基因功能參考文獻(xiàn)：
- Suppression of CDCA7L limits multiple myeloma proliferation through apoptosis. PMID: 27882933
- We identify the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in medulloblastoma PMID: 27013196
- common LEDGF/p75 interaction interface shared by JPO2, PogZ, MLL1, IWS1 and HIV IN PMID: 26245978
- The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 and MYC. PMID: 25480495
- Data indicate that JPO2 and LEDGF/p75 interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75. PMID: 24634210
- CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC progression. PMID: 24141559
- Reduction in R1 repressor protein correlates significantly with an increase (approximately 40%) in monoamine oxidase A protein levels within the major depressive disorder groups compared with controls. PMID: 21654740
- monoamine oxidase A activation of glucocorticoids and androgens is regulated differently by R1 and Sp1 PMID: 16728402
- demonstrates the functions of MAO A and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways PMID: 16829576
- Over-expression of JPO2 resulted in a modest but reproducible inhibition of HIV-1 replication, consistent with competition between integrase and JPO2 for binding to LEDGF/p75 PMID: 17669426
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亞細(xì)胞定位：Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
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組織特異性：Ubiquitous. Overexpressed in medulloblastoma.
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