CDC23 Antibody

說明書

產品詳情

Uniprot No.：

Q9UJX2
基因名：

CDC23
別名：

ANAPC8 antibody; Anaphase promoting complex subunit 8 antibody; Anaphase-promoting complex subunit 8 antibody; Apc 8 antibody; APC8 antibody; Cdc 23 antibody; CDC23 antibody; CDC23_HUMAN antibody; cell division cycle 23 antibody; Cell division cycle 23 homolog antibody; Cell division cycle protein 23 antibody; Cell division cycle protein 23 homolog antibody; Cut23 antibody; Cyclosome subunit 8 antibody
反應種屬：

Human,Mouse,Rat
免疫原：

Human CDC23
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
基因功能參考文獻：
1. Results identified CDC23 as a miR-34c-regulated target that could be responsible for the miR-34c-induced cell cycle arrest. PMID: 25064703
2. CDC23 is a critical regulator of cell cycle and cell growth, may be involved in thyroid cancer initiation and progression, and may explain the different tumor biology observed by gender. PMID: 21990323
3. Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A PMID: 21336306
4. We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 which are known to be key function elements. PMID: 12629511
蛋白家族：

APC8/CDC23 family
數據庫鏈接：

HGNC: 1724

OMIM: 603462

KEGG: hsa:8697

STRING: 9606.ENSP00000378350

UniGene: Hs.73625

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