CDC14A Antibody

說明書

中文名稱：

CDC14A兔多克隆抗體
貨號：

CSB-PA154120
規(guī)格：

￥2024
圖片：
Western blot analysis of extracts from HeLa cells, using CC14A antibody.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CDC14A Polyclonal antibody
Uniprot No.：

Q9UNH5
基因名：

CDC14A
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from Internal of Human CC14A.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
基因功能參考文獻：
1. Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. Authors therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy. PMID: 28465438
2. Mutations in CDC14A gene are associated with Autosomal-Recessive Severe to Profound Deafness. PMID: 27259055
3. Overexpressed miR-301a may increase CDC14A expression and promote cell proliferation and migration in osteosarcomacells. Therefore, miR- 301a may be useful for osteosarcoma diagnosis and therapy. PMID: 27323075
4. hCDC14A is down-regulated in many tumor tissues and reduced hCDC14A expression is correlated with poorer survival of patients with cancer PMID: 26747605
5. These findings indicated that ZIPK may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A. PMID: 25503649
6. hCdc14A might be involved in cell cycle regulation in cultured human brain vascular endothelial cells during high glucose-, free fatty acids-, and hypoxia-induced injury. PMID: 25463242
7. Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes. PMID: 21233601
8. Cdc14A phosphatase prevents premature activation of Cdk1 regulating Cdc25A and Cdc25B at the entry into mitosis. PMID: 20956543
9. human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14A are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation. PMID: 20479464
10. human Cdc14A phosphatase disrupts centrosome separation PMID: 11901424
11. Data suggest that hCdc14A phosphatase plays a role in the regulation of the centrosome cycle, mitosis, and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells. PMID: 12134069
12. analysis of iron-responsive elements in the 3'UTR of CDC14a protein PMID: 16760464
13. hCdc14A is differentially expressed in human cancer cells and can interact with both p53 and the Cdk1/cyclin B complex; it may play a role in carcinogenesis PMID: 16784539
14. Cdc14A may be involved in the cell cycle regulation of Cdc25A stability. PMID: 17172867
15. RN-tre phosphorylation is critical for efficient hCdc14A association PMID: 17371873
16. PLK1-HsCdc14A interaction provides a temporal regulation of HsCdc14A in chromosome segregation during mitosis. PMID: 17623655
17. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225
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相關疾病：

Deafness, autosomal recessive, 105 (DFNB105)
亞細胞定位：

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Cell projection, kinocilium. Cell projection, stereocilium.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily
數(shù)據(jù)庫鏈接：

HGNC: 1718

OMIM: 603504

KEGG: hsa:8556

STRING: 9606.ENSP00000354916

UniGene: Hs.127411

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