CD300LF Antibody

中文名稱：

CD300LF兔多克隆抗體
貨號：

CSB-PA819470LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA819470LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA819470LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CD300LF Polyclonal antibody
Uniprot No.：

Q8TDQ1
基因名：

CD300LF
別名：

CD300 antigen like family member antibody; CD300 antigen-like family member F antibody; CD300 molecule like family member f antibody; CD300f antibody; CD300LF antibody; CLM antibody; CLM-1 antibody; CLM1 antibody; CLM1_HUMAN antibody; CMRF35-like molecule 1 antibody; IGSF antibody; IgSF13 antibody; Immune receptor expressed on myeloid cells 1 antibody; immune receptor expressed on myeloid cells antibody; immunoglobin superfamily member antibody; Immunoglobulin superfamily member 13 antibody; Immunoglobulin superfamily member antibody; Inhibitory receptor IREM1 antibody; IREM antibody; IREM-1 antibody; IREM1 antibody; Nepmucin antibody; NK inhibitory receptor antibody; NKIR antibody; TREM antibody; triggering receptors expressed on myeloid cells antibody; UNQ3105/PRO10111 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human CMRF35-like molecule 1 protein (20-156AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CD300LF Antibody (CSB-PA819470LA01HU)，的標記方式是Non-conjugated。對于CD300LF Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA819470LB01HU	CD300LF Antibody, HRP conjugated	ELISA
FITC	CSB-PA819470LC01HU	CD300LF Antibody, FITC conjugated
Biotin	CSB-PA819470LD01HU	CD300LF Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.
基因功能參考文獻：
1. this study demonstrates the role of CD300f in governing innate immune eosinophil activities in pediatric Crohn's disease patients and in active ulcerative colitis patients PMID: 27118491
2. findings suggest that two rare heterozygous truncating variations (RPS24 Q191X and CD300LF P261fsX266) are risk candidates for autism spectrum disorder. PMID: 25601189
3. The data suggest that the neuroprotective role of CD300f would be the result of a complex network of cell interactions. PMID: 21951326
4. peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling PMID: 22288587
5. CD300f blocked the activation of cells induced by all TLR ligands PMID: 22043923
6. Data indicate that CD300F is an active regulator of TLR-mediated macrophage activation through association with SHP-1 involving MyD88 and/or TRIF. PMID: 21536801
7. Findings indicate that IREM-1 exerted its inhibitory effect on BAFF-medicated signalling through ITIM-mediated regulation of ERK activities in THP-1 cells. PMID: 20646006
8. IgSF13 was identified from dendritic cells; preferentially expressed in myelo-monocytic cells, including monocytes, monocyte-derived DC and monocyte-related cell lines; may be involved in the negative regulation of specific leukocyte population [IgSF13] PMID: 15184070
9. a novel inhibitory receptor of the Ig superfamily in myeloid cells. (IREM-1 = immune receptor expressed on myeloid cells-1) PMID: 15549731
10. reveal a putative functional duality of the IREM-1 myeloid cell receptor PMID: 17202342
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

CD300 family
組織特異性：

Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocy
數據庫鏈接：

HGNC: 29883

OMIM: 609807

KEGG: hsa:146722

STRING: 9606.ENSP00000327075

UniGene: Hs.567706

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