CCT5 Antibody

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CCT5 Polyclonal antibody
Uniprot No.：

P48643
基因名：

CCT5
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from internal of Human CCT5.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
基因功能參考文獻：
1. CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex PMID: 25995452
2. H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5. PMID: 25124038
3. introduction of the truncated human CCT epsilon subunit into yeast cells PMID: 22232265
4. A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia. PMID: 16399879
相關疾病：

Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP)
亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

TCP-1 chaperonin family
數據庫鏈接：

HGNC: 1618

OMIM: 256840

KEGG: hsa:22948

STRING: 9606.ENSP00000280326

UniGene: Hs.1600

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