CCNDBP1 Antibody

說明書

中文名稱：

CCNDBP1兔多克隆抗體
貨號：

CSB-PA004816GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O95273
基因名：

CCNDBP1
別名：

AU022347 antibody; CCDB1_HUMAN antibody; CCNDBP 1 antibody; Ccndbp1 antibody; Cyclin D type binding protein 1 antibody; Cyclin-D1-binding protein 1 antibody; D type cyclin interacting protein 1 antibody; DIP 1 antibody; DIP1 antibody; GCIP antibody; Grap 2 and cyclin D interacting protein antibody; Grap 2 cyclin D interacting protein GCIP antibody; Grap 2 cyclin interacting protein antibody; Grap2 and cyclin D interacting protein antibody; Grap2 and cyclin-D-interacting protein antibody; Grap2 cyclin D interacting protein GCIP antibody; Grap2 cyclin interacting protein antibody; HHM antibody; HHM protein antibody; Human homolog of Maid antibody; MAID antibody; MAID protein antibody; Maternal inhibition of differentiation antibody; MGC109078 antibody; OTTMUSP00000017037 antibody; RP23 263D22.2 antibody; SECC 8 antibody; SSEC 8 antibody; Stage specific embryonic cDNA 8 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human CCNDBP1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC,IF
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
基因功能參考文獻：
1. Data suggest MAID/CCNDBP1 inhibits cell migration induced by TGFB1 (transforming growth factor-beta1) but not by BMP4 (bone morphogenetic protein-4); MAID does not alter cell proliferation, epithelial-mesenchymal transition, or TGFB3-induced apoptosis. PMID: 26002959
2. GCIP underexpression is associated with Osteosarcoma. PMID: 26107195
3. Data indicate that grap2 and cyclin D1 interacting protein (GCIP) and inhibitor of of DNA binding/differentiation 1 (Id1) are inversely expressed in non-small cell lung cancer (NSCLC) cell lines and specimens. PMID: 24970809
4. The first structure of a free-standing human dominant-negative helix-loop-helix protein (DIP1) was reported. DIP1 adopts a V-shaped conformation, with N-terminal and C-terminal five-helix bundles connected by the HLH region. PMID: 22453338
5. It is proposed for the first time that Rad may promote carcinogenesis at least in part by inhibiting GCIP-mediated tumor suppression. PMID: 20460530
6. In transgenic mice, GCIP functions as a transcriptional suppressor, regulates cyclin D1 expression, inhibits cell growth and colony formation in human HepG2 cells, suggesting GCIP plays a significant role in tumor initiation and development. PMID: 16501603
7. CT847 interacts with mammalian Grap2 cyclin D-interacting protein PMID: 17532760
8. P0 overexpression may cause tumorigenesis in breast and liver tissues at least in part by inhibiting GCIP-mediated tumor suppression. PMID: 17621266
9. Data suggest that HHM/Maid regulates a subset of TGF-beta target genes including the Olig1-Smad synexpression group. PMID: 18923419
10. decreased expression of GCIP in vivo is present in human breast carcinoma. PMID: 18983464
11. Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator PMID: 19153449
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

CCNDBP1 family
組織特異性：

Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
數據庫鏈接：

HGNC: 1587

OMIM: 607089

KEGG: hsa:23582

STRING: 9606.ENSP00000300213

UniGene: Hs.36794

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