CCL13 Antibody

說明書

中文名稱：

CCL13兔多克隆抗體
貨號：

CSB-PA937680
規格：

￥1100
圖片：
Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: 293T cells, Primary antibody: CSB-PA937680(CCL13 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

Uniprot No.：

Q99616
基因名：

CCL13
別名：

C-C motif chemokine 13 antibody; CCL13 antibody; CCL13_HUMAN antibody; Chemokine (C C motif) ligand 13 antibody; CK beta 10 antibody; CK-beta-10 antibody; CKb10 antibody; MCP-4 antibody; MGC17134 antibody; Monocyte chemoattractant protein 4 antibody; Monocyte chemotactic protein 4 antibody; NCC 1 antibody; NCC-1 antibody; NCC1 antibody; New CC chemokine 1 antibody; SCYA13 antibody; SCYL1 antibody; short chain antibody; Small inducible cytokine A13 precursor antibody; Small inducible cytokine subfamily A (Cys Cys) member 13 antibody; Small-inducible cytokine A13 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human CCL13
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
基因功能參考文獻：
1. CCL13 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
2. CCL13 levels in serum and synovial fluid may serve as a biomarker for the progression of osteoarthritis. PMID: 25654294
3. CCL13 is an antimicrobial protein with bacteriocidal activity against E. coli. PMID: 12949249
4. Data suggest that CCL13 binds to several chemokine receptors (CCR1, CCR2, and CCR3), allowing CCL13 to elicit different effects on target cells of immune system. CCL13 is involved in pathology of chronic inflammatory/autoimmune diseases. [REVIEW] PMID: 23846739
5. MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease. PMID: 23375121
6. E(2) has adverse effects on the pathogenesis of RA as a result of unregulated cell death, increased TNF-alpha-induced MMP-3 production, and CCL13 overproduction, subsequently resulting in the disease progression of RA. PMID: 22393877
7. Findings suggest that the pro-atherogenic effects of CCR2 may not be restricted to interaction with MCP-1, but could also involve activation by MCP-4, being an inflammatory link between platelet and monocyte activation. PMID: 20139115
8. Data suggest that the monocyte chemoattractant protein-4 core promoter YY-1 binding motif is functional, and modulates the transcriptional regulation of the MCP-4 gene. PMID: 12805085
9. The study was undertaken to understand the relationship between the functional proteomics of receptor-Ck and developmental stages of human atherosclerotic aortic wall. PMID: 14560935
10. MCP-4 may be a critical molecule that links obesity and chronic inflammation. PMID: 16855189
11. The Th2 cytokine IL-4 preferentially stimulated MCP-4 expression. PMID: 17541284
12. interferon-gamma with IL-1beta/TNF-alpha activates the production of CCL13 from chondrocytes in RA joints; secreted CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated MAP kinases cascade PMID: 17824960
13. TLR2, 3, 4 and 5 ligands, but not TLR7/8 or 9 ligands, synergized with IL-4 to induce the production of MCP-4 in nasal polyp fibroblasts. PMID: 17851891
14. CCL13 and HSPC159 mRNA expressions in PBMC are up-regulated specifically in MCNS patients during the nephrosis phase. PMID: 18219197
15. Oncostatin M can strongly up-regulate the expression of CCL13, a chemokine recently identified in the synovial fluid of patients with rheumatoid arthritis. PMID: 19565514
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亞細胞定位：

Secreted.
蛋白家族：

Intercrine beta (chemokine CC) family
組織特異性：

Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
數據庫鏈接：

HGNC: 10611

OMIM: 601391

KEGG: hsa:6357

STRING: 9606.ENSP00000225844

UniGene: Hs.414629

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