CCDC22 Antibody
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中文名稱：CCDC22兔多克隆抗體
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貨號：CSB-PA004681GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：CCDC22
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別名：AI481216 antibody; CCD22_HUMAN antibody; Ccdc22 antibody; chromosome X open reading frame 37 antibody; Coiled-coil domain-containing protein 22 antibody; CXorf37 antibody; DXImx40e antibody; JM1 antibody; RGD1560910 antibody; Sfc22 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human CCDC22
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.; (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.
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基因功能參考文獻(xiàn)：
- SNPs within the CCDC22 gene are associated with increased susceptibility to endometriosis in Brazilian women. PMID: 28470452
- Our results suggest that rs2294020 is associated with the risk of several autoimmune diseases in European populations, specifically with diseases that present themselves, among else, in the skin. PMID: 27888057
- CCDC22 mutation is associated with hypercholesterolemia. PMID: 26965651
- Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome PMID: 24916641
- CCDC22 participates in NF-kappaB activation and its deficiency leads to decreased IkappaB turnover PMID: 23563313
- This study demonistrated that CCDC22 is a novel candidate gene for syndromic X-linked intellectual disability. PMID: 21826058
- Identifies the homologous mouse protein as a copine-binding protein. PMID: 12522145
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相關(guān)疾病：Ritscher-Schinzel syndrome 2 (RTSC2)
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亞細(xì)胞定位：Endosome.
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蛋白家族：CCDC22 family
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組織特異性：Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle.
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數(shù)據(jù)庫鏈接：
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