CBX8 Antibody

說明書

中文名稱：

CBX8兔多克隆抗體
貨號：

CSB-PA864026ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: CBX8 antibody at 2μg/ml + Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 43 kDa
Observed band size: 43 kDa

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA864026ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA864026ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA864026ESR2HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CBX8 Polyclonal antibody
Uniprot No.：

Q9HC52
基因名：

CBX8
別名：

Cbx8 antibody; CBX8_HUMAN antibody; Chromobox Homolog 8 (Drosophila Pc Class) antibody; Chromobox Homolog 8 (Pc Class Homolog; Drosophila) antibody; Chromobox Homolog 8 antibody; Chromobox protein homolog 8 antibody; hPc3 antibody; Pc Class 3 Homolog (Drosophila) antibody; Pc Class 3 Homolog antibody; Pc3 antibody; Polycomb 3 antibody; Polycomb 3 homolog antibody; RC1 antibody; Rectachrome 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Chromobox protein homolog 8 protein (80-280AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
基因功能參考文獻：
1. CBX8 functions as an oncogene to upregulate EGR1 and miR-365-3p to stimulate the AKT/beta-catenin pathway in hepatocellular carcinoma.CBX8 expression is increased and associated with poor outcomes in hepatocellular carcinoma. PMID: 29066512
2. CBX8 binds with the Snai1 promoter, represses Snai1 transcription and suppresses esophageal carcinoma metastasis. PMID: 28912889
3. The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients. PMID: 28837252
4. CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1-BCOR complex at BCL6 binding sites to specifically silence genes in the germinal center and promote lymphomagenesis PMID: 27505670
5. CBX8 plates roles in epigenetic regulation in DNA damage response. PMID: 27555324
6. IGF1 can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression PMID: 25398592
7. The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues. PMID: 26837964
8. These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment. PMID: 26718407
9. Low CBX8 expression was associated with distant metastasis in colorectal cancer. PMID: 25360999
10. CBX8 might emerge as an oncogene for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy. PMID: 25197352
11. The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics. PMID: 24460908
12. Interaction with CBX8 precludes AF9-DOT1L binding. PMID: 23891621
13. CBX8 cooperated with SIRT1 for suppressing p53 acetylation induced by Sirtinol and etoposide/TSA. Upon ectopic expression, CBX8 or SIRT1 repressed the expression of p21(WAF1) by inhibiting p53 binding to the promoter. PMID: 23474493
14. CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. PMID: 22094252
15. CBX8 is an essential component of one of the polycomb repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF locus, involved in cell-fate decisions. PMID: 17332741
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亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 15962

OMIM: 617354

KEGG: hsa:57332

STRING: 9606.ENSP00000269385

UniGene: Hs.387258

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