The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA205503(CBS Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse pancreas tissue, human fetal liver tissue, Primary antibody: CSB-PA205503(CBS Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
相關疾病:
Cystathionine beta-synthase deficiency (CBSD)
亞細胞定位:
Cytoplasm. Nucleus.
蛋白家族:
Cysteine synthase/cystathionine beta-synthase family
組織特異性:
In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.