CBR3 Antibody

說明書

中文名稱：

CBR3兔多克隆抗體
貨號：

CSB-PA669024
規格：

￥2024
圖片：
Western blot analysis of extracts from MCF7 cells and Jurkat cells, using CBR3 antibody.

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using CBR3 antibody.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CBR3 Polyclonal antibody
Uniprot No.：

O75828
基因名：

CBR3
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from internal of Human CBR3.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).
基因功能參考文獻：
1. CBR3 730G>A is significantly associated with recurrence- free survival in patients who received intravesical chemotherapy with pirarubicin after complete transurethral resection. PMID: 30125887
2. No significant correlation between cardiotoxicity and SNPs within the CBR pathway. Further investigation into CBR SNPs in a larger adult sample is needed. PMID: 26563179
3. association of SNPs in ABCB1 and CBR3 with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines. PMID: 26799497
4. Variants of CBR3 and GSTP1 enzymes may be associated with changes in short-term functional cardiac parameters. PMID: 23182048
5. genetic polymorphism in the CBR3 gene conferred risk of type 2 diabetes and insulin resistance in Chinese. The association was probably mediated through modulation of adipogenesis. PMID: 22527884
6. CBR3 polymorphisms contribute to increased cardiomyopathy risk associated with anthracycline treatment of childhood cancer. PMID: 22124095
7. CBR3 is a novel target gene of inflammatory stimuli; elucidation of its detailed role in inflammation deserves further investigation. PMID: 22425771
8. Computational searches identify a conserved antioxidant response element(ARE) in the distal carbonyl reductase 3 (CBR3) promoter region. PMID: 22001310
9. The CBR3 distal promoter contains an activating cis-regulatory element that is responsive to Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
10. CBR3 is regulated via NRF2-dependent signaling pathways, a finding and plays an important role in the cellular response to oxidative stress. PMID: 20806931
11. analysis of the structural basis for substrate specificity in human monomeric carbonyl reductases CBR3 PMID: 19841672
12. The common carbonyl reductase 3 (CBR3)valine244methionine polymorphism encodes for CBR3 isoforms with distinctive enzymatic properties, as revealed in DNA variation panels from 10 ethnic groups. PMID: 15537833
13. There was a trend toward an association between the CBR3 V244M polymorphism and the risk of CHf PMID: 18457324
14. Polymorphisms in CBR3 may explain interindividual and interethnic variability of doxorubicin pharmacokinetics and pharmacodynamics. PMID: 18551042
15. CBR3 polymorphisms have no significant influence on the pharmacokinetics of doxorubicin in Asian breast cancer patients. PMID: 19016765
16. identified the promoter of human CBR3. Liver samples from black donors showed higher relative CBR3 mRNA levels than samples from whites PMID: 19590938
17. carbonyl reductase has an important function in modifying the metastatic behavior of malignant tumors. PMID: 10728668
18. Decreased Carbonyl Reductase expression in epithelial ovarian cancer is associated with RLN metastasis and poor survival PMID: 11592776
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亞細胞定位：

Cytoplasm.
蛋白家族：

Short-chain dehydrogenases/reductases (SDR) family
組織特異性：

Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.
數據庫鏈接：

HGNC: 1549

OMIM: 603608

KEGG: hsa:874

STRING: 9606.ENSP00000290354

UniGene: Hs.154510

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