CBFA2T2 Antibody

說明書

中文名稱：

CBFA2T2兔多克隆抗體
貨號：

CSB-PA004575ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: CBFA2T2antibody at 2.45μg/ml + Raji whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 68, 64, 29, 66 kDa
Observed band size: 68, 40 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004575ESR1HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CBFA2T2 Polyclonal antibody
Uniprot No.：

O43439
基因名：

CBFA2T2
別名：

AML1 MTG8 antibody; cbfa2t2 antibody; Core binding factor runt domain alpha subunit 2 translocated to 2 antibody; core-binding factor; runt domain; alpha subunit 2 antibody; DKFZp313F2116 antibody; EHT antibody; ETO homolog on chromosome 20 antibody; ETO homologous on chromosome 20 antibody; MTG 8 like protein antibody; MTG 8 related protein 1 antibody; MTG8 like protein antibody; MTG8 related protein 1 antibody; MTG8-like protein antibody; MTG8-related protein 1 antibody; MTG8R_HUMAN antibody; MTGR 1 antibody; Myeloid translocation gene related protein 1 antibody; Myeloid translocation related protein 1 antibody; Myeloid translocation-related protein 1 antibody; p85 antibody; Protein CBFA2T2 antibody; ZMYND 3 antibody; ZMYND3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein CBFA2T2 protein (325-604AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner. Can repress the expression of MMP7 in a ZBTB33-dependent manner. May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation.
基因功能參考文獻：
1. in human colorectal cancer (CRC) samples MTGR1 was downregulated at both the transcript and protein level. Overall data indicates that MTGR1 has a context-dependent effect on intestinal tumorigenesis. PMID: 27270437
2. CBFA2T2 forms a biochemical complex with PRDM14, a germline-specific transcription factor; mechanistically, CBFA2T2 oligomerizes to form a scaffold upon which PRDM14 and OCT4 are stabilized on chromatin PMID: 27281218
3. The MTGR1 gene depends on a GC-box-rich sequence for transcriptional regulation and possible ubiquitous expression. PMID: 22443175
4. report characterization of two chimeric transcripts identified in AML translocation cases involving CBFA2T2 and C20orf112 PMID: 20520637
5. ETO family member-mediated oligomerization and repression can be distinct events and that interaction between ETO family members and hSIN3B or N-CoR may not necessarily strengthen transcriptional repression. PMID: 18586123
6. These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth. PMID: 19026687
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相關疾病：

A chromosomal aberration involving CBFA2T2 is found in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL). Translocation t(9;20)(p13;q11) with PAX5.
亞細胞定位：

Nucleus.
蛋白家族：

CBFA2T family
組織特異性：

Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.
數據庫鏈接：

HGNC: 1536

OMIM: 603672

KEGG: hsa:9139

STRING: 9606.ENSP00000262653

UniGene: Hs.153934

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