CASZ1 Antibody

中文名稱：

CASZ1兔多克隆抗體
貨號：

CSB-PA773036LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: CASZ1 antibody at 4.8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 191, 125 kDa
Observed band size: 191 kDa

IHC image of CSB-PA773036LA01HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CASZ1 Polyclonal antibody
Uniprot No.：

Q86V15
基因名：

CASZ1
別名：

2410019P08Rik antibody; AV096627 antibody; BC040081 antibody; BOS_15820 antibody; Castor-related protein antibody; CASZ1 antibody; CASZ1_HUMAN antibody; CST antibody; D4Ertd432e antibody; dJ734G22.1 antibody; FLJ12223 antibody; FLJ20321 antibody; MGC155102 antibody; MGC31683 antibody; OTTMUSP00000011746 antibody; OTTMUSP00000011748 antibody; Putative survival-related protein antibody; RP23-230I5.1 antibody; RP4-734G22.2 antibody; SRG antibody; Survival related antibody; Zinc finger protein 693 antibody; Zinc finger protein castor homolog 1 antibody; ZNF693 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Zinc finger protein castor homolog 1 protein (127-266AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CASZ1 Antibody (CSB-PA773036LA01HU)，的標記方式是Non-conjugated。對于CASZ1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA773036LB01HU	CASZ1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA773036LC01HU	CASZ1 Antibody, FITC conjugated
Biotin	CSB-PA773036LD01HU	CASZ1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
基因功能參考文獻：
1. Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM) PMID: 28945738
2. These findings provide insight into mechanisms by which CASZ1 regulates transcription, and suggests that regulation of CASZ1 subcellular localization may impact its function in normal development and pathologic conditions such as NB tumorigenesis. PMID: 27270431
3. The current study reveals CASZ1 as a new gene responsible for human dilated cardiomyopathy (DCM), which provides novel mechanistic insight and potential therapeutic target for CASZ1-associated DCM, implying potential implications in improved prophylactic and therapeutic strategies for DCM, the most common type of primary myocardial disease. PMID: 28099117
4. the current study firstly identifies CASZ1 as a new gene predisposing to congenital heart disease in humans PMID: 27693370
5. CASZ1b binds to chromatin and recruits NuRD complexes to orchestrate epigenetic-mediated transcriptional programs PMID: 26296975
6. CASZ1 inhibits cell cycle progression in neuroblastoma by restoring retinoblastoma protein activity. PMID: 23892435
7. Papillomavirus DNA integration is associated with loss of CASZ1 gene and thus cervical carcinogenesis. PMID: 22262398
8. This study identifies key domains needed for CASZ1b to regulate gene transcription; a link between loss of CASZ1b transcriptional activity and attenuation of CASZ1b-mediated inhibition of neuroblastoma growth and tumorigenicity PMID: 22331471
9. determined that the tumor suppressors CLU, NGFR, and RUNX3 were also directly repressed by EZH2 like CASZ1 in NB cells PMID: 22068036
10. CASZ1 is a critical modulator of neural cell development, and that somatically acquired disruption of normal CASZ1 expression contributes to the malignant phenotype of human Neuroblastoma. PMID: 21252912
11. The study indicates that although their mechanisms of regulation may be distinct, both CASZ1b and CASZ1a have largely redundant but critical roles in suppressing tumor cell growth. PMID: 21490919
12. CASZ1 is expressed in a number of human tumors and localizes to a chromosomal region frequently lost in tumors of neuroectodermal origin. PMID: 16631614
顯示更多

收起更多
亞細胞定位：

Nucleus.
組織特異性：

Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain.
數據庫鏈接：

HGNC: 26002

OMIM: 609895

KEGG: hsa:54897

STRING: 9606.ENSP00000366221

UniGene: Hs.439894

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human