CANT1 Antibody

說明書

中文名稱：

CANT1兔多克隆抗體
貨號：

CSB-PA848824ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA848824ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CANT1 Polyclonal antibody
Uniprot No.：

Q8WVQ1
基因名：

CANT1
別名：

Apyrase antibody; Apyrase homolog antibody; Ca2+ dependent endoplasmic reticulum nucleoside diphosphatase antibody; Calcium activated nucleotidase 1 antibody; CANT 1 antibody; CANT1 antibody; CANT1_HUMAN antibody; Putative MAPK activating protein PM09 antibody; Putative MAPK-activating protein PM09 antibody; Putative NF kappa B activating protein 107 antibody; Putative NF-kappa-B-activating protein 107 antibody; SCAN 1 antibody; SCAN-1 antibody; SHAPY antibody; Soluble Ca activated nucleotidase isozyme 1 antibody; Soluble calcium activated nucleotidase 1 antibody; Soluble calcium activated nucleotidase SCAN 1 antibody; Soluble calcium-activated nucleotidase 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Soluble calcium-activated nucleotidase 1 protein (102-401AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
基因功能參考文獻：
1. CANT1 long non-coding RNA triggers efficient therapeutic efficacy by correcting aberrant long non-coding cascade in malignant uveal melanoma. PMID: 28330694
2. The Multiple Epiphyseal Dysplasia (MED)phenotype is thus allelic to the more severe Desbuquois dysplasia phenotype and the results identify CANT1 as a second locus for recessively inherited MED PMID: 28742282
3. a novel mutation of CANT1, c.467C>T (p.Ser156Phe) in 3 Indian patients with Desbuquois dysplasia, Kim type from 2 families PMID: 25486376
4. Data studied proteoglycan synthesis in CANT1 mutated patient fibroblasts, and found significant reduced GAG synthesis in presence of beta-D-xyloside, suggesting that CANT1 plays a role in proteoglycan metabolism. PMID: 22539336
5. Novel mutations in the CANT1 gene are reported in three cases of Desbuquois dysplasia type I and fetal hydrops. PMID: 21654728
6. estimated the age of the founder mutation as approximately 1420 years PMID: 21412251
7. CANT1 is commonly overexpressed in the vast majority of primary prostate carcinomas and in the precursor lesion PIN and may represent a novel prognostic biomarker PMID: 21435463
8. The clinical-radiographic spectrum produced by CANT1 mutations must be extended to include Desbuquois dysplasia type 2 and Kim variant. PMID: 21037275
9. Cloning, expression, and characterization of this calcium-acdtivated enzyme, a human enzyme belonging to a new family of extracellular nucleotidases. PMID: 12234496
10. This soluble apyrase is a calcium-binding protein, as evident from saturable Ca2+-dependent changes in intrinsic tryptophan fluorescence, UV difference absorption spectra, and Ca2+-triggered transition from enzymatically inactive form to active enzyme. PMID: 12600208
11. The importance of the dimeric state for enzymatic activity and biological function in this nucleotidase by mutating isoleucine 170, is investigated. PMID: 18067325
12. human soluble calcium-activated nucleotidase inhibits coagulation in vitro and thrombosis in vivo PMID: 18222531
13. The two novel ETV4 fusion partners possess as predominant common characteristics androgen-induction and prostate-specific expression. PMID: 18451133
14. Mutations in CANT1 in Desbuquois dysplasia are identified. PMID: 19853239
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相關疾病：

Desbuquois dysplasia 1 (DBQD1); Epiphyseal dysplasia, multiple, 7 (EDM7)
亞細胞定位：

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cell membrane. Note=Processed form: Secreted.
蛋白家族：

Apyrase family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 19721

OMIM: 251450

KEGG: hsa:124583

STRING: 9606.ENSP00000307674

UniGene: Hs.8859

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