CALCR Antibody

說明書

中文名稱：

CALCR兔多克隆抗體
貨號：

CSB-PA153268
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA153268(CALCR Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

P30988
基因名：

CALCR
別名：

CALCR; Calcitonin receptor; CT-R
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human CALCR
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:5000
IHC	1:15-1:50

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.; Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase. Does not undergo receptor internalization following ligand binding.
基因功能參考文獻：
1. CTR activates AKAP2-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 and claudin 3. PMID: 28428082
2. structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Galphasbetagamma protein determined by Volta phase-plate single-particle cryo-electron microscopy PMID: 28437792
3. Data suggest that a single GlcNAc residue at CTR N130 (asparagine 130) is responsible for enhanced affinity of calcitonin for CTR ECD; the same appears to apply for enhanced affinity of amylin for RAMP2-CTR ECD. [GlcNAc = N-acetylglucosamine; CTR = calcitonin receptor; ECD = extracellular domain; RAMP2 = receptor (calcitonin) activity modifying protein 2]. PMID: 28614667
4. Males with CALCR TT genotype (rs1801197) have 13 fold increased risk for kidney stone disease. No significant association of rs1042138 with kidney stone in West Bengal, India. PMID: 28435134
5. Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS. PMID: 26895962
6. An association between fluorosis and the Alu I polymorphism in the CTR gene was observed in fluoride-exposed populations. PMID: 25402775
7. The C1377T polymorphism in the CTR gene is associated with bone mineral density at the lumbar spine in a postmenopausal Han Chinese population PMID: 25055932
8. There was no statistically significant difference in CTR gene nucleotide sequence polymorphisms at 1377-bp between Chinese Xinjiang Han and Uygur patients with primary osteoporosis. PMID: 24522475
9. Data indicate a potential association between 3'UTR+18C>T and intron 1 polymorphisms in the CALCR and the risk of kidney stone disease. PMID: 24296906
10. Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PMID: 24643196
11. High calcitonin receptor is associated with prostate cancer. PMID: 23820954
12. CTR was expressed by glioma cells in a majority of GBM tumours tested. PMID: 22335784
13. Allele C in CALCR gene was associated with reduced bone mass in cystic fibrosis children. PMID: 21462477
14. highly expressed on normal T- and B-lymphocytes PMID: 19445988
15. Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. PMID: 19903822
16. relationship between calcitonin receptor (CTR) genotype and buccal marginal bone loss observed at stage II surgery for endosseous implants PMID: 11858573
17. an important role for filamin in the endocytic sorting and recycling of the internalized CTR PMID: 12531889
18. Co-expression of calcitonin receptors (CT) lacking a portion of domain 1 with receptor activity-modifying protein (RAMP) 1, 2, or 3 appears to produce functional CT-(8-32)-sensitive adrenomedullin receptors. PMID: 12565884
19. ALUI calcitonin receptor polymorphism genotype showed a positive association with prevalence of osteoporosis in the subjects PMID: 12771454
20. analysis of the amino terminus of the calcitonin receptor and its effects on docking constraints PMID: 14583624
21. the site of attachment of a photoaffinity label was identified as residue Leu(348) within the third extracellular loop of the receptor PMID: 15155765
22. existence of two novel splice variants of human CTR and splicing patterns could be involved in the post-transcriptional regulation of the gene. PMID: 15563840
23. Effects of VDR (Fok-I) and CTR gene polymorphism contribute to understanding of pathogenesis of urinary calculi. Potential candidate gene in search for genetic causes of paediatric calcium oxalate nephrolithiasis. PMID: 15856322
24. normal cell surface expression, mobilization of intracellular calcium, and Erk activation requires the cytoplasmic C-terminal tail of the CTR PMID: 15860547
25. The calcitonin receptor model is consistent with cooperative interaction between the receptor amino terminus and the receptor core. PMID: 15929987
26. the MCP-1-induced TRAP(+)/CTR(+) multinuclear cells represent an arrested stage in osteoclast differentiation, after NFATc1 induction and cellular fusion but prior to the development of bone resorption activity PMID: 16280328
27. up-regulation of CT biosynthesis and activation of CT-CTR axis in primary prostate tumors may have direct relevance in their progression to the metastatic phenotype. PMID: 17487556
28. Study data suggest that the AluI polymorphism of the CTR gene can be useful as a genetic marker in the interindividual susceptibility of QUS parameters by the interaction with nutritional status as a lifestyle factor. PMID: 17709929
29. High calcitonin receptor is associated with multiple myeloma PMID: 17714780
30. BsmI and AluI polymorphisms are not related to the forearm bone values either reflecting mass or geometrical variables in this male population. PMID: 18622089
31. the juxtamembranous region of the amino terminus of the family B G protein-coupled calcitonin receptor plays a critical role in small-molecule agonist action PMID: 19447889
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 2 family
數據庫鏈接：

HGNC: 1440

OMIM: 114131

KEGG: hsa:799

STRING: 9606.ENSP00000352561

UniGene: Hs.489127

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