CACNA2D1 Antibody

中文名稱：

CACNA2D1兔多克隆抗體
貨號：

CSB-PA004407LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of Hela cells with CSB-PA004407LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA004407LA01HU at dilution of 1:100
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靶點詳情

產品詳情

產品描述：

The CACNA2D1 polyclonal antibody was produced by introducing the recombinant human voltage-dependent calcium channel subunit alpha-2/delta-1 protein (577-717aa) into rabbits and inducing an immune response that produces antibodies against the CACNA2D1 protein. The rabbit's blood was then collected, and the serum containing the CACNA2D1 polyclonal antibodies was isolated and purified via protein G chromatography. It has high purity, up to 95%, which ensures accurate and reliable results.

The CACNA2D1 polyclonal antibody is capable of reacting with human samples. It has been tested in ELISA, IHC, and IF applications, allowing for the detection of the presence and quantity, visualization of distribution and localization, and identification of the CACNA2D1 protein.
產品名稱：

Rabbit anti-Homo sapiens (Human) CACNA2D1 Polyclonal antibody
Uniprot No.：

P54289
基因名：

CACNA2D1
別名：

CA2D1_HUMAN antibody; CACN A2 antibody; CACNA2 antibody; Cacna2d1 antibody; CACNL2A antibody; Calcium channel L type alpha 2 polypeptide antibody; Calcium channel voltage dependent alpha 2/delta subunit 1 antibody; CCHL2A antibody; Dihydropyridine receptor alpha 2 subunit antibody; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit antibody; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta antibody; L type calcium channel subunit alpha 2 antibody; MHS 3 antibody; MHS3 antibody; Voltage dependent calcium channel subunit alpha 2/delta 1 antibody; Voltage gated calcium channel subunit alpha 2/delta 1 antibody; Voltage-dependent calcium channel subunit delta-1 antibody; Voltage-gated calcium channel subunit alpha-2/delta-1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-1 protein (577-717AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CACNA2D1 Antibody (CSB-PA004407LA01HU)，的標記方式是Non-conjugated。對于CACNA2D1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA004407LB01HU	CACNA2D1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004407LC01HU	CACNA2D1 Antibody, FITC conjugated
Biotin	CSB-PA004407LD01HU	CACNA2D1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
基因功能參考文獻：
1. Using human genome-wide association study (GWAS) data, evidence for association of a CACNA2D1 single-nucleotide polymorphism and primary open angle glaucoma is found. PMID: 29176626
2. we report an additional patient with the 7q21.11 deletion syndrome and provide evidence that haploinsufficiency for a single gene may not be the disease mechanism. In vitro studies of the interaction between PCLO and CACNA2D1 will be required to examine the hypothesis that combined haploinsufficiency for these two synaptic proteins results in neuronal dysfunction PMID: 28240412
3. All three patients present with epilepsy and intellectual disability pinpointing the CACNA2D1 gene as an interesting candidate gene for these clinical features. PMID: 25074461
4. Compound mutation of CACNA2D1 and RANGRF genes were found. To the best of our knowledge, this is the first comprehensive description of the concurrence of these two mutations and histiocytoid cardiomyopathy. PMID: 24438356
5. High prevalence of CACNA2D1, SCN5A, and CACNB2 genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data. PMID: 23414114
6. Functional expression of CACNA2D1 is inhibited by prion protein expression with competition at glycosylphosphatidylinositol. PMID: 24329154
7. this study reports the identification and characterization of the human alpha2delta-1 subunit gene promoter region and its regulation by specific transcription factor 1. PMID: 23242029
8. (Review) In neurons, alpha2delta1 subunits are present mainly in presynaptic terminals; peripheral sensory nerve injury results in up-regulation of alpha2delta1 in dorsal root ganglion neurons, and there is consequent increase in trafficking of alpha2delta1 to their terminals. PMID: 20579869
9. In neocortical slices from transgenic mice having a point mutation (i.e., R217A) of the alpha2delta-1 subunit of voltage-sensitive calcium channels, pregabalin does not affect potassium-evoked glutamate release, yet inhibits this release in wild-type mice. PMID: 21464332
10. Results show that mutation of CACNA2D1 gene causes a new varant of SCTS. PMID: 21383000
11. CACNA2D1 is a novel Brugada Syndrome susceptibility gene. PMID: 20817017
12. CACNA2D1 has structural domains which contribute to the regulation of N-type calcium channel inactivation PMID: 14602720
13. Timothy syndrome is a disease of excessive cellular Ca(2+) entry and life-threatening arrhythmias caused by a mutation in the primary cardiac L-type Ca(2+) channel (Ca(V)1.2). PMID: 19001023
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Calcium channel subunit alpha-2/delta family
組織特異性：

Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.
數據庫鏈接：

HGNC: 1399

OMIM: 114204

KEGG: hsa:781

STRING: 9606.ENSP00000349320

UniGene: Hs.282151

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