CA6 Antibody

中文名稱：

CA6兔多克隆抗體
貨號：

CSB-PA004377LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human salivary gland tissue using CSB-PA004377LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CA6 Polyclonal antibody
Uniprot No.：

P23280
基因名：

CA6
別名：

CA VI antibody; CA-VI antibody; CA6 antibody; CAH6_HUMAN antibody; Carbonate dehydratase VI antibody; Carbonic anhydrase 6 antibody; Carbonic anhydrase VI antibody; carbonic anhydrase VI nirs variant 1 antibody; carbonic anhydrase VI nirs variant 3 antibody; GUSTIN antibody; MGC21256 antibody; Salivary carbonic anhydrase antibody; Secreted carbonic anhydrase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Carbonic anhydrase 6 protein (17-172AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CA6 Antibody (CSB-PA004377LA01HU)，的標記方式是Non-conjugated。對于CA6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA004377LB01HU	CA6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004377LC01HU	CA6 Antibody, FITC conjugated
Biotin	CSB-PA004377LD01HU	CA6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Reversible hydration of carbon dioxide. Its role in saliva is unknown.
基因功能參考文獻：
1. The current study suggests that genetic variation in TAS2R38 and CA6 influences picky eating in preschoolers. PMID: 28858874
2. Anti-CA6 was the most prevalent novel autoantibody in patients with dry eye, and was associated with younger age and more severe disease. Longitudinal studies are needed to determine whether anti-CA6 is a marker for early Sjogren's syndrome. PMID: 29504954
3. CA6 is a specific marker for serous acinar cells of salivary glands and acinic cell carcinoma (AciCC). PMID: 26212680
4. genetic association studies in population of elderly women in Poland: Data suggest that SNPs in TAS2R38 (rs713598, rs1726866, rs10246939) and an SNP in CA6 (rs2274333) are associated with intake of and preferences for some foods (coffee and white cabbage) among the population studied. (TAS2R38 = taste receptor type 2 member 38; CA6 = carbonic anhydrase VI) PMID: 28455260
5. Results found that the CA VI gene polymorphism rs2274327 showed no correlation between salivary parameters and dental-oral health status in Eastern Anatolian Turkish children. PMID: 27100223
6. dental plaque amount, lactobacilli count, age, and saliva buffer capacity, as well as CA6 (T55M) gene polymorphism, explained total of 87.8% of variations in DMFT scores. PMID: 26377569
7. We also found that the haplotype (ACA) (rs2274328, rs17032907 and rs11576766)of the carbonic anhydrase VI was associated with a low number of decayed, missing, and filled teeth index with an odds ratio (95% confidence interval) of 0.635 (0.440-0.918). PMID: 26125798
8. Study showed that PROP (6-n-propylthiouracil) bitterness was due to TAS2R38 diplotypes, whereas the density of fungiform papillae was more closely associated with gustin genotypes PMID: 25447475
9. SNPs associated with taste perception and taste bud anatomy PMID: 24534176
10. results suggest that polymorphisms in the CA6 gene are associated with the concentrations of secreted CA VI. PMID: 23652931
11. The rs2274333 polymorphism of the gustin gene affects PROP sensitivity. PMID: 24040192
12. The aim of this study was to investigate carbonic anhydrase (CA) VI Exon 2 single nucleotide polymorphism (SNP) and its possible association with salivary parameters in type 2 diabetic patients compared to healthy adults. PMID: 22198626
13. The 1.9A crystal structure of the human CA VI catalytic domain reveals a prototypical mammalian CA fold, and a novel dimeric arrangement as compared to previously-reported CA structures. PMID: 22366092
14. The data of this study showed how the combination of the TAS2R38 and gustin gene genotypes modulate PROP phenotype. PMID: 21712049
15. The polymerase chain reaction followed by restriction fragment length polymorphism assay described here can be used as an alternative to sequencing in bitter taster status research, and could be employed as a survey tool in nutrigenomic studies. PMID: 21631296
16. The gustin gene dimorphism rs2274333 observed in supertaster and nontaster subjects may influence the protein conformation and, thereby, affect zinc ion binding. PMID: 20631203
17. analysis of allele & genotype distribution of 3 polymorphisms in CA6 gene; no association between polymorphisms in exons 2 & 3 & caries experience; positive association between salivary buffer capacity & rs2274327 PMID: 19721466
18. The cloning, expression and purification of this isozyme are reported. PMID: 17499996
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亞細胞定位：

Secreted.
蛋白家族：

Alpha-carbonic anhydrase family
組織特異性：

Major constituent of saliva.
數據庫鏈接：

HGNC: 1380

OMIM: 114780

KEGG: hsa:765

STRING: 9606.ENSP00000366662

UniGene: Hs.100322

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