C1QTNF5 Antibody

說明書

中文名稱：

C1QTNF5兔多克隆抗體
貨號：

CSB-PA031979
規(guī)格：

￥1100
圖片：
Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: CSB-PA031979(C1QTNF5 Antibody) at dilution 1/300, Secondary antibody: Donkey anti Guinea pig IgG at 1/8000 dilution, Exposure time: 5 seconds
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q9BXJ0
基因名：

C1QTNF5
別名：

C1QTNF5 antibody; CTRP5 antibody; UNQ303/PRO344 antibody; Complement C1q tumor necrosis factor-related protein 5 antibody
宿主：

Guinea pig
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human C1QTNF5
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

基因功能參考文獻(xiàn)：
1. High myonectin expression is associated with Type 2 Diabetes. PMID: 29161407
2. In children adipocyte C1QTNF5 expression is already strongly related to the degree of obesity and is associated with obesity-related AT alterations, systemic CTRP5 serum levels as well as circulating markers of metabolic disease and is positively regulated by TNFalpha in vitro PMID: 28239164
3. Sequencing of C1QTNF5 revealed 28 unique variants although none showed a statistically significant association with dt-GA when compared with 1000G individuals. PMID: 27149696
4. Our results provide the first genetic and physiological evidence for CTRP5 as a negative regulator of glucose metabolism and insulin sensitivity. Inhibition of CTRP5 action may result in the alleviation of insulin resistance associated with obesity and diabetes. PMID: 27143553
5. Late-onset retinal degeneration, proven to have the p.Ser163Arg mutation in C1QTNF5, and asked whether retina-wide sub-RPE deposit was detectable and quantifiable. PMID: 25010528
6. C1QTNF5 monomers can multimerize into a bouquet-like octadecamer. PMID: 24531000
7. CTRP-5 might be a novel adipokine that circulates abundantly in human sera. PMID: 23430573
8. C1QTNF5 retinopathy is an autosomal dominant LORD resulting in a complex ocular phenotype involving the RPE and ciliary epithelium. SD-OCT findings revealed widespread photoreceptor loss and diffuse choroidal thinning. PMID: 23289492
9. cloning of the bicistronic transcript and characterization of the upstream ORF, MFRP PMID: 11263980
10. The crystal structure of the trimeric globular domain of human C1QTNF5 at 1.34A resolution reveals unique features of this novel C1q family member. PMID: 22892318
11. Late-onset retinal degeneration is a progressive degeneration, and anterior segment abnormalities present early. PMID: 22277927
12. pathogenic role of C1qtnf5 Ser163Arg mutation PMID: 22110650
13. A physiological function for C1QTNF5 (myonectin) in linking insulin resistance with quantitative changes in mtDNA. PMID: 22031510
14. This study revealed the presence of a functional promoter for the CTRP5 gene located 5' of its start site. PMID: 20554618
15. CTRP5 has a role in extracellular deposit formation in late-onset retinal degeneration PMID: 12944416
16. A single locus at 11q23 is implicated in a complex ocular phenotype involving RPE and CE, tissues of neuroectodermal origin. PMID: 16123441
17. In this family with a proven mutation in this gene, peripupillary iris atrophy and abnormally long anterior zonular insertions were present before retinal changes and visual loss. PMID: 16376663
18. L-ORMD is due to insufficient levels of secreted C1QTNF5, compromised RPE cell function resulting from ER retention of the mutant protein or both mechanisms. PMID: 16600989
19. C1QTNF5 has a role in late-onset retinal degeneration PMID: 17249553
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相關(guān)疾病：

Late-onset retinal degeneration (LORD)
亞細(xì)胞定位：

Secreted.
數(shù)據(jù)庫鏈接：

HGNC: 14344

OMIM: 605670

KEGG: hsa:114902

STRING: 9606.ENSP00000402389

UniGene: Hs.632102

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