Bag3 Antibody
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中文名稱：Bag3兔多克隆抗體
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貨號：CSB-PA864372HA01MO
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規格：￥440
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圖片：
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Immunoprecipitating Bag3 in K562 whole cell lysate
Lane 1: Rabbit control IgG (1µg) instead of CSB-PA864372HA01MO in K562 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA864372HA01MO (6µg) + K562 whole cell lysate (500µg)
Lane 3: K562 whole cell lysate (10µg)
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其他：
產品詳情
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產品名稱：Rabbit anti-Mus musculus (Mouse) Bag3 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Bag3 antibody; Bis antibody; MNCb-2243BAG family molecular chaperone regulator 3 antibody; BAG-3 antibody; Bcl-2-associated athanogene 3 antibody; Bcl-2-binding protein Bis antibody
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宿主：Rabbit
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反應種屬：Mouse
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免疫原：Recombinant Mouse BAG family molecular chaperone regulator 3 protein (2-577AA)
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免疫原種屬：Mus musculus (Mouse)
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標記方式：Non-conjugated
本頁面中的產品，Bag3 Antibody (CSB-PA864372HA01MO)，的標記方式是Non-conjugated。對于Bag3 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IP
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推薦稀釋比：
Application Recommended Dilution IP 1:200-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.
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基因功能參考文獻：
- expression of the co-chaperone BAG3 and other chaperone-assisted selective autophagy factors was analyzed in the cellular, zebrafish and ky/ky mouse models. PMID: 29914939
- It is a cochaperone that mediates autophagy. PMID: 29304346
- Thus, BAG3 is critical for the protein turnover of small HSPs via activation of autophagy in the heart. PMID: 29409895
- BAG3 plays a relevant role in regulating SNCA clearance via macroautophagy, and the heat shock protein 70-BAG3-sequestosome 1 complex may be involved in this process. PMID: 28941726
- BAG3 directly stabilizes hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells. PMID: 29114069
- BAG3 expression is required for neuronal differentiation and migration. PMID: 28144784
- interaction between BAG3 and HSP70 is essential for BAG3 to stabilize small heat shock proteins and maintain cardiomyocyte protein homeostasis PMID: 28737513
- The spatial regulation of mTORC1 exerted by BAG3 apparently provides the basis for a simultaneous induction of autophagy and protein synthesis to maintain the proteome under mechanical strain. PMID: 27756573
- Genetic variation in BAG3 plays an important role in the prevention of ischemic tissue necrosis. PMID: 28442482
- The aim of this study was to investigate the possible hemodynamic effects of BAG3 performing both in vitro and in vivo experiments. PMID: 27763645
- Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. PMID: 26796036
- molecular association of MyHC and BIS is necessary for MyHC stabilization in skeletal muscle. PMID: 27034027
- BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. PMID: 26522614
- Bis is upregulated in astrocytes after hypoxia-ischemia; hypoxia-ischemia induces progressive cell death in the hippocampi of bis-positive mice, while hippocampal neurons are less vulnerable to hypoxia-ischemia in mice that lack Bis. PMID: 22907804
- Deletion of the bis gene results in a marked increase in the production of corticosterone that is associated with thymic atrophy. PMID: 21540452
- BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. PMID: 20884878
- Results indicate that Bis functions to mediate cellular regulation of the stem cell niche on the vascular compartment. PMID: 20024912
- BAG3 alters the interaction between HSP70 and IKKgamma, increasing availability of IKKgamma and protecting it from proteasome-dependent degradation; this, in turn, results in increased NF-kappaB activity and survival PMID: 20368414
- BAG3 is not required for muscle development, this co-chaperone appears to be critically important for maintenance of mature skeletal muscle. PMID: 16936253
- The absence of Bis has considerable influences on postnatal growth and survival, possibly due to a nutritional impairment. PMID: 18840758
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亞細胞定位：Nucleus. Cytoplasm.
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