BST1 Antibody

說明書

中文名稱：

BST1兔多克隆抗體
貨號：

CSB-PA159485
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA159485(BST1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA159485(BST1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q10588
基因名：

BST1
別名：

ADP ribosyl cyclase 2 antibody; ADP-ribosyl cyclase 2 antibody; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 antibody; Bone marrow stromal antigen 1 antibody; Bone marrow stromal cell antigen 1 antibody; BST 1 antibody; BST-1 antibody; BST1 antibody; BST1_HUMAN antibody; cADPr hydrolase 2 antibody; CD157 antibody; CD157 antigen antibody; Cyclic ADP ribose hydrolase 2 antibody; Cyclic ADP-ribose hydrolase 2 antibody; NAD(+) nucleosidase antibody; OTTHUMP00000217617 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human BST1
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
基因功能參考文獻(xiàn)：
1. SNPs rs28532698 and rs4301112 in CD157 are not significantly associated with childhood autism spectrum disorder or the severity of the disease in a Chinese Han population. PMID: 29216786
2. the rs4698412 variant of BST-1 may increase the Parkinson disease susceptibility. [META-ANALYSIS] PMID: 25986899
3. Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells. PMID: 24413464
4. A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157. PMID: 25250980
5. Studies indicate that vertebrate ADP-ribosyl cyclases (ARCs) Bst1 and CD38 with common gene structure of invertebrate ARC, suggesting the origin to the ancestor of bilaterian animals. PMID: 24896331
6. Autism and with features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript. PMID: 24634087
7. BST1 rs11724635 polymorphism can interact with well water drinking to increase the risk of Parkinson's disease in a Taiwanese population. PMID: 24342025
8. These findings indicate a central role of CD157 in cell-extracellular matrix interactions and make CD157 an attractive therapeutic target in inflammation and cancer. PMID: 24753259
9. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in Parkinson's disease. PMID: 24795584
10. A ligand-receptor complex SCRG1/BST1 axis facilitate mesenchymal stem cells migration, preserve OCT4 and CD271 expression, self-renewal and osteogenic differentiation. PMID: 24413464
11. The results of this study indicated that the SNCA and BST1 SNPs generally increase the risk of developing PD and that SNCA rs11931074 in particular is associated with a higher risk of parkinson disease with family history. PMID: 23853107
12. The results of this study showed that no causative mutation in the BST1 gene in patients with Parkinson's disease. PMID: 23827523
13. This study confirmed the associations of BST1 with parkinson disease susceptibility and fail to show significant associations of alzheimer disease genome-wide association study (GWAS) top hits with PD susceptibility in a Korean population. PMID: 23820587
14. BST1 SNPs rs11931532, rs12645693, & rs11724635 did not correlate with sporadic PD. The relationship of rs11724635 & sporadic PD had borderline significance. Smoking or caffeine intake did not correlate with SNP rs11724635 affecting sporadic PD. PMID: 23026536
15. Findings implicate CD157 in the progression of EOC to metastatic disease and suggest that CD157 may represent a valuable therapeutic target. PMID: 22916288
16. The SNPs investigated in the BST1, PARK15 and PARK9 genes associated with PD susceptibility are not associated with PD in the northern Han Chinese population. PMID: 22490479
17. Direct replication of single nucleotide polymorphisms (SNPs) within SNCA and BST1 confirmed these two genes to be associated with the Parkinson's Disease in the Netherlands. PMID: 21248740
18. The CD157-integrin partnership provides optimal adhesion and transmigration of human monocytes. PMID: 21478153
19. found converging evidence of association with Parkinson's disease on 12q24 (rs4964469, combined P = 2.4 x 10(-7)) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 x 10(-6)), previously reported in Japanese data PMID: 21084426
20. PARK16, PARK8, and PARK1 loci but not BST1 are found to be associated with Parkinson's disease. PMID: 20697102
21. CD157 plays a pivotal role in the control of ovarian cancer cell migration and peritoneal invasion, and it may be clinically useful as a prognostic tool and therapeutic target. PMID: 20639476
22. crystal structures of the extracellular region of human BST-1 at atomic resolution in the free form and in complexes with five substrate analogues: nicotinamide, NMN, ATPgammaS, ethenoNADP, and ethenoNAD PMID: 11866528
23. CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties [review] PMID: 12415565
24. Deficient in paroxysmal nocturnal hemoglobinemia; crucial to regulation of innate immunity during inflammation. PMID: 15328157
25. The results confirm that CD157 physically interacts with CD11b/CD18 complex in human neutrophils PMID: 18211745
26. Results show that CD38 and CD157 are expressed constitutively by corneal cells: CD38 appears as a 45-kDa monomer, while CD157 is a 42- to 45-kDa doublet. PMID: 19052657
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亞細(xì)胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

ADP-ribosyl cyclase family
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 1118

OMIM: 600387

KEGG: hsa:683

STRING: 9606.ENSP00000265016

UniGene: Hs.720344

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