Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.
基因功能參考文獻:
BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine. PMID: 25472445
BNIP-2 directly interacted with the motor and tail domains of KIF5B via its BCH domain. PMID: 25378581
Data imply that SIRT1 may mediate MPP(+)-induced cytotoxicity, possibly through the regulation of BNIP2. PMID: 21130087
Inhibition of BNIP-2 expression did not affect the susceptibility to NK cell-mediated killing. PMID: 20704564
Transfection of the bnip2 cDNA in neuroblastoma cell line results in massive cell death counteracted by Bcl-2 overexpression; bnip2 is the mediator of the anti-apoptotic activity of estrogens in a variety of cells PMID: 11744098
BNIP-2 has a role in regulating cell dynamics with a novel Rho GTPase-activating protein, BPGAP1 PMID: 12944407
BNIP-2 in vivo induces cell dynamics by recruiting Cdc42 PMID: 15652341
Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities. PMID: 17961507
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亞細胞定位:
Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures.