Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
基因功能參考文獻:
BEST2 and BEST4 could be added to the lineage-specific genes of humans intestinal epithelial cells PMID: 24223998
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon PMID: 20407206
These data suggest that Best2 may play a functional role in the regulation of aqueous flow and drainage in humans. PMID: 20157619
identified three novel VMD2-related human genes demonstrating a high degree of conservation in their respective RFP-TM domains [VMD2L1, VMD2L2, VMD2L3] PMID: 12032738
Results provide evidence that the bestrophins are expressed in pancreatic duct cells and, more specifically, that hBest1 plays a role in the calcium activated chloride channels found in these cells. PMID: 19237432
we examine data obtained from tissue-type and animal models and discuss the current state of bestrophin research, what roles Best2 may play in ocular epithelia and electrophysiology, how perturbation of these functions may result in disease. [REVIEW] PMID: 19398034
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亞細胞定位:
Cell membrane; Multi-pass membrane protein.
蛋白家族:
Bestrophin family
組織特異性:
Mainly confined to the retinal pigment epithelium and colon.