BAG4 Antibody
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中文名稱：BAG4兔多克隆抗體
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貨號：CSB-PA092457
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規格：￥1100
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圖片：
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Gel: 8%SDS-PAGE, Lysate: 60 μg, Lane: Human normal stomach tissue, Primary antibody: CSB-PA092457(BAG4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 7 minutes
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：BAG 4 antibody; BAG family molecular chaperone regulator 4 antibody; BAG-4 antibody; BAG4 antibody; BAG4_HUMAN antibody; Bcl 2 associated athanogene 4 antibody; Bcl-2-associated athanogene 4 antibody; BCL2 associated athanogene 4 antibody; Silencer of death domains antibody; SODD antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide of Human BAG4
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.
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基因功能參考文獻：
- AGS cells overexpressing BAG4 exhibited a significant increase in the percentage of cells in the G1/G0 peak and transfection of shRNA decrese demonstrated the opposite effect. PMID: 29067445
- acid-induced increase in SODD expression and decrease in cell apoptosis may depend on the activation of NOX5-S and NF-kappaB1 p50 in FLO cells PMID: 27756772
- SGK1.1 regulates gene transcription upon a different set of genes some of which participate in cell survival pathways (BAG-4) and others in intracellular vesicular traffic (Brox). PMID: 25849655
- SODD over-expression might be correlated with the clinical classification, curative effect, and prognosis of ALL cells. PMID: 24737427
- MicroRNA-26a is strongly downregulated in melanoma and induces cell death through repression of silencer of death domains (SODD). PMID: 23190898
- Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells. PMID: 12017295
- SODD/BAG-4 is not only a silencer of TNFR1 but also a modulator of CD95 activity, regulating the balance of both death-promoting and -depressing signals PMID: 12706861
- BAG-4 functions as a negative regulator for apobec-1-mediated apoB mRNA editing PMID: 14559896
- Gene induces transformed phenotype when overexpressed in a cancer breast cell line. PMID: 17178857
- results of analysis of the genome-wide scan data was a 20 cM region at 8p11-23 in which markers had LODs > or =1.0. Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 and BAG4. PMID: 17366557
- Vincristine induces Jurkat cell apoptosis by downregulating expression of SODD protein and priming the death receptor pathway. PMID: 17605853
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亞細胞定位：Cytoplasm.
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組織特異性：Ubiquitous.
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數據庫鏈接：
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