B3GALTL Antibody

說明書

中文名稱：

B3GALTL兔多克隆抗體
貨號(hào)：

CSB-PA004623
規(guī)格：

￥1090
圖片：
Western Blot analysis of HepG2 cells using β-1,3-Gal-TL Polyclonal Antibody
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q6Y288
基因名：

B3GLCT
別名：

B3GLCT antibody; B3GALTL antibody; B3GTLBeta-1,3-glucosyltransferase antibody; Beta3Glc-T antibody; EC 2.4.1.- antibody; Beta 3-glucosyltransferase antibody; Beta-3-glycosyltransferase-like antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from the C-terminal region of Human β-1,3-Gal-TL.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.
基因功能參考文獻(xiàn)：
1. Studies indicate that Peters Plus syndrome is caused by mutations in beta 3-glucosyltransferase (B3GALTL). PMID: 27049305
2. POFUT2 and B3GLCT mediate a noncanonical endoplasmic reticulum quality-control mechanism that recognizes folded thrombospondin type 1 repeats and stabilizes them by glycosylation. PMID: 25544610
3. Mutations in the coding region of B3GALTL were identified in nine patients; six had a documented phenotype of classic Peters plus syndrome (PPS) and the remaining three had a clinical diagnosis of PPS with incomplete clinical documentation. PMID: 23889335
4. a novel c.597-2 A>G splicing mutation within the B3GALTL gene in typical Peters-plus syndrome PMID: 23954224
5. A novel homozygous c.597-2A>G mutation was identified in both patients with Peters plus syndrome harbouring a novel splice site mutation in the B3GALTL gene PMID: 22759511
6. Vertebral defects in a patient with Peters plus syndrome and mutations in B3GALTL. PMID: 21671750
7. The present report confirms the wide clinical spectrum of Peters plus syndrome, underlines the major clinical criteria of the syndrome and the major implication of B3GALTL gene in this condition. PMID: 21067481
8. Novel B3GALTL mutation in Peters-plus Syndrome PMID: 19796186
9. B3GTL is transcribed in a wide range of tissues and has conserved domains and motifs PMID: 12943678
10. We report here the molecular cloning and characterization of a novel beta1,3-glucosyltransferase (beta3Glc-T) that synthesizes a Glcbeta1,3Fucalpha- structure on the TSR domain. PMID: 16899492
11. Biallelic truncating mutations in the beta 1,3-galactosyltransferase-like gene (B3GALTL) in all 20 tested patients, showed that Peters Plus is a monogenic, primarily single-mutation syndrome. PMID: 16909395
12. Peters Plus syndrome is a new congenital disorder of glycosylation and involves defective Omicron-glycosylation of thrombospondin type 1 repeats.( PMID: 18199743
13. two new mutant alleles, c.459 + 1G > A and c.230insT, were identified and predicted to result in truncated protein products; data confirm an important role for B3GALTL in causing typical Peters Plus syndrome PMID: 18798333
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相關(guān)疾病：

Peters-plus syndrome (PPLS)
亞細(xì)胞定位：

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 31 family
組織特異性：

Widely expressed, with highest levels in testis and uterus.
數(shù)據(jù)庫鏈接：

HGNC: 20207

OMIM: 261540

KEGG: hsa:145173

STRING: 9606.ENSP00000343002

UniGene: Hs.13205

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