Actb Antibody, Biotin conjugated

說明書

中文名稱：

Actb兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA07675D0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Actb Polyclonal antibody
Uniprot No.：

P60710
基因名：

Actb
別名：

ActbActin antibody; cytoplasmic 1 antibody; Beta-actin) [Cleaved into: Actin antibody; cytoplasmic 1 antibody; N-terminally processed] antibody
宿主：

Rabbit
反應種屬：

Mouse
免疫原：

Recombinant Mouse Actin, cytoplasmic 1 protein (11-375AA)
免疫原種屬：

Mus musculus (Mouse)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
基因功能參考文獻：
1. Data, including data from studies using knockout mice, suggest that Actb and Actg1 are enriched in isolated membrane preparations from skeletal muscle which represent interface between mitochondria and sarco-endoplasmic reticulum; these structures appear to be important in signaling, mitochondrial dynamics, and muscle relaxation. (Actb = beta actin cytoplasmic 1; Actg1 = actin gamma cytoplasmic 1) PMID: 29265728
2. Essential nucleotide- and protein-dependent functions of Actb/beta-actin. PMID: 30012594
3. These results suggest a a novel genome-wide mechanism where the polymerase-associated beta-actin synergizes with NM1 to coordinate permissive chromatin with Pol I transcription, cell growth, and proliferation. PMID: 27127100
4. Two actin isoforms, beta- and gamma-actin, are crucial for slow, rapid, bulk, and overshoot endocytosis at large calyx-type synapses, and for slow endocytosis and bulk endocytosis at small hippocampal synapses. PMID: 27840001
5. Melatonin treatment for 1 h increased monomeric actin and decreased polymeric actin. PMID: 28209510
6. Disruption of the in vivo interaction of KIF11 with ZBP1 delocalizes beta-actin mRNA and affects cell migration. PMID: 25588836
7. TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells. PMID: 24766723
8. Actin binding proteins associated with stress fiber or focal adhesion formation are overexpressed in the beta-actin knock-out cells and many of these contain CH-, LIM- or EFh- domains. PMID: 24123846
9. Absence of beta-actin severely hampers formation of the peripheral nervous system, due to defective neural crest migration. PMID: 24409333
10. Data indicate that ectopic phosphatidylinositol 3,4,5-triphosphate (PIP3) elevation alone activated membranes to form actin-based structures whose behavior was similar to that of growth-cone-like "waves". PMID: 23951027
11. this work demonstrated that dendritic beta-actin messenger RNA and ribosomes are in a masked, neuron-specific form. PMID: 24458642
12. chorein interacts with beta-adducin and beta-actin. PMID: 24129186
13. RNA polymerase II, glyceraldehyde-3-phosphate dehydrogenase (Gapdh), and hypoxanthine phophoribosyltransferase (Hprt) show a more stable gene expression as candidate genes than do ribosomal 18s and Actb. PMID: 22735032
14. The findings suggested that local translation of beta-actin in growth cones of motoneurons is regulated by laminin signalling and that this signalling is disturbed in survival of motoneuron protein-deficient motoneurons. PMID: 22810847
15. Data suggest that in beta-actin knockout cells other actins compensate for beta-actin in cell migration process. PMID: 22448045
16. Data indicate that Ubc and Ywhaz were best correlated for B cells and lymphocytes, whereas Ubc and Gapdh were the best combination for non-B cells, and Actb and Hprt1 were the least stably expressed genes for B cells and non-B cell. PMID: 22884776
17. the zipcode-binding protein 1 transports beta-actin mRNA to the focal adhesion compartment, it dwells for minutes, associating its localization with motility through the formation of stable connections between adhesions and newly synthesized actin filaments PMID: 22948660
18. These data show that thymosinbeta4 and beta-actin are over-expressed during nurse cell formation upon T. spiralis infection and may be involved in nurse cell formation along with other actin-binding proteins. PMID: 22305657
19. novel roles for beta-actin in promoting complex CNS tissue architecture PMID: 22403730
20. Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes. PMID: 21778137
21. These data support an essential role for beta-actin in regulating cell migration and gene expression through control of the cellular G-actin pool PMID: 21900491
22. Perturbing the dystrophin and beta actin interaction results in quadriceps myopathy. PMID: 21325027
23. Nuclear beta-actin controls growth arrest of epithelial cells. PMID: 21172822
24. Results demonstrate overlapping developmental roles but unique post-developmental functions for beta-actin and gamma-actin in maintaining hair cell stereocilia. PMID: 20976199
25. Data show that exposure to hyperoxia resulted in significant increases in eNOS-beta-actin association, eNOS activity, and protein tyrosine nitration in the lungs. PMID: 20826796
26. arginylated gamma-actin, unlike beta-, was highly unstable and selectively ubiquitinated and degraded in vivo; instability was regulated by differences in nucleotide coding sequence between the actin isoforms, which conferred different translation rates PMID: 20847274
27. HnRNP-R-mediated axonal beta-actin mRNA translocation plays an essential physiological role for axon growth and presynaptic differentiation. PMID: 20167579
28. Dystrophin and utrophin bind actin through distinct modes of contact PMID: 16478721
29. beta-actin was arginylated in vivo to regulate actin filament properties, beta-actin localization, and lamella formation in motile cells PMID: 16794040
30. Data show that beta-actin characteristic markers of brush borders, become abnormally distributed along these atypical basolateral membranes in gal3(-/-) mice. PMID: 18211959
31. The cytoplasmic beta-actin (Actb) gene generates two alternative transcripts terminated at tandem polyA sites. PMID: 18835850
32. Ischemia-mediated aggregation of the actin cytoskeleton is one of the major initial events resulting in ischemia-reperfusion injury. PMID: 19095765
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亞細胞定位：

Cytoplasm, cytoskeleton. Nucleus.
蛋白家族：

Actin family
組織特異性：

Expressed in the epididymis (at protein level). Expressed in the kidney (at protein level).
數據庫鏈接：

KEGG: mmu:11461

STRING: 10090.ENSMUSP00000098066

UniGene: Mm.328431

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