AVEN Antibody
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中文名稱：AVEN兔多克隆抗體
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貨號(hào)：CSB-PA335882
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA335882(AVEN Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA335882(AVEN Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) -
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Raji cells, Hela cells, Primary antibody: CSB-PA335882(AVEN Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：AVEN
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別名：1700013A01Rik antibody; 1700056A21Rik antibody; Apoptosis caspase activation inhibitor antibody; AVEN antibody; AVEN_HUMAN antibody; Cell death regulator Aven antibody; mAven L antibody; mAven S antibody; MGC124011 antibody; OTTMUSP00000016129 antibody; PDCD12 antibody; Programmed cell death 12 antibody; RP23-52C15.2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthetic peptide of Human AVEN
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:25-1:100 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情
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功能：Protects against apoptosis mediated by Apaf-1.
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基因功能參考文獻(xiàn)：
- AVEN and BIRC6 are inhibited by combination therapy of miR-30e and proanthocyanidin in glioblastoma stem cells PMID: 27388765
- The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes. PMID: 26267306
- the expression of Aven is regulated by the Akt signaling pathway through cathepsin D activity, which contributes to the sensitivity of cancer cells to chemotherapeutic agents. PMID: 25573060
- The findings implicate Aven in ATR-Chk1 signalling and point towards Chk1 inhibition as a strategy to sensitize human osteosarcomas to chemotherapy. PMID: 25757065
- Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms. PMID: 22751129
- a model of Aven activation by which its N-terminal inhibitory domain is removed by CathD-mediated proteolysis, thereby unleashing its cytoprotective function. PMID: 22388353
- The results suggest that deregulation of the expression of the apoptosis inhibitor Aven may be related to male factor infertility. PMID: 21718987
- the expression level of aven mRNA in de novo AML patients obviously increases PMID: 20030919
- Results suggest that the regulation of Exportin-1/CRM1-dependent nucleocytoplasmatic traffic of Aven could modulate its ability to influence cell cycle progression. PMID: 20935510
- Aven expression was found to be higher in patients >or=10 years old or <1 year, and with unfavorable cytogenetic abnormalities. It was also significantly higher in relapsed patients in the standard-risk group and an independent poor prognostic factor. PMID: 16388850
- point mutation observed by transcriptome sequencing of malignant pleural mesothelioma tumors PMID: 18303113
- These results identify Aven as a new ATM activator and describe a positive feedback loop operating between Aven and ATM; in aggregate, these findings place Aven, a known apoptotic inhibitor, as a critical transducer of the DNA-damage signal. PMID: 18571408
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亞細(xì)胞定位：Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes.
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組織特異性：Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.
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數(shù)據(jù)庫(kù)鏈接：
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