ATP6V1E1 Antibody, FITC conjugated

說明書

中文名稱：

ATP6V1E1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA02295C0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ATP6V1E1 Polyclonal antibody
Uniprot No.：

P36543
基因名：

ATP6V1E1
別名：

ATP6V1E1 antibody; ATP6E antibody; ATP6E2 antibody; V-type proton ATPase subunit E 1 antibody; V-ATPase subunit E 1 antibody; V-ATPase 31 kDa subunit antibody; p31 antibody; Vacuolar proton pump subunit E 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human V-type proton ATPase subunit E 1 protein (2-224AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
基因功能參考文獻：
1. expression of the V-ATPase V1E1 has prognostic significance in esophageal squamous cell carcinoma, and is closely linked to migration, invasion, and aerobic glycolysis in esophageal cancer cells PMID: 27384996
2. Low-grade PanIN lesions with typical columnar morphology displayed diffuse labeling of the V1E subunit. In advanced lesions it was found along the basolateral membranes. PMID: 25072283
3. The genes CECR2, SLC25A18 and ATP6V1E1, mapping within the critical region for cat eye syndrome (CES), may be responsible for anorectal, renal and preauricular anomalies in patients with CES. PMID: 22395867
4. Data demonstrate the physiological significance of the interaction between the E and H subunits of V-ATPase and extend previous studies on the arrangement of subunits on the peripheral stalk of V-ATPase. PMID: 12163484
5. HuR shows increased binding to some V-ATPase mRNAs during ATP depletion; siRNA-mediated knockdown of HuR results in diminished V-ATPase expression PMID: 16155006
6. Rat vacuolar H(+)ATPase associates with NHE-RF (Na(+)/H(+) exchanger regulatory factor); the E subunit was co-immunoprecipitated from rat kidney cytosol with NHE-RF antibodies. PMID: 10748165
7. The mouse V-ATPase E may participate in the regulation of the mSos1-dependent Rac1 signaling pathway involved in growth factor receptor-mediated cell growth control. PMID: 11560919
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相關疾病：

Cutis laxa, autosomal recessive, 2C (ARCL2C)
亞細胞定位：

Apical cell membrane.
蛋白家族：

V-ATPase E subunit family
組織特異性：

Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level). Ubiquitous. High expression in the skin.
數據庫鏈接：

HGNC: 857

OMIM: 108746

KEGG: hsa:529

STRING: 9606.ENSP00000253413

UniGene: Hs.517338

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