ATP2C2 Antibody

中文名稱：

ATP2C2兔多克隆抗體
貨號：

CSB-PA002340LA01HU
規(guī)格：

￥440
圖片：
Immunofluorescence staining of A549 cells with CSB-PA002340LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ATP2C2 Polyclonal antibody
Uniprot No.：

O75185
基因名：

ATP2C2
別名：

AT2C2_HUMAN antibody; ATP2C2 antibody; ATPase 2C2 antibody; ATPase; Ca++ transporting; type 2C; member 2 antibody; Calcium-transporting ATPase type 2C member 2 antibody; DKFZp686H22230 antibody; hSPCA2 antibody; KIAA0703 antibody; PMR1 antibody; Secretory pathway Ca(2+)-ATPase 2 antibody; secretory pathway calcium ATPase 2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Calcium-transporting ATPase type 2C member 2 protein (621-702AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，ATP2C2 Antibody (CSB-PA002340LA01HU)，的標(biāo)記方式是Non-conjugated。對于ATP2C2 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA002340LB01HU	ATP2C2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002340LC01HU	ATP2C2 Antibody, FITC conjugated
Biotin	CSB-PA002340LD01HU	ATP2C2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus.
基因功能參考文獻(xiàn)：
1. In total, four independent SNPs within DYX1C1 and ATP2C2 were found to be associated with MMR stronger than expected from multiple testing. To explore potential pathomechanisms, we annotated these variants with functional data including tissue-specific expression analysis and eQTLs. PMID: 29201552
2. The Secretory Pathway Ca(2+) -ATPases SPCA1 and SPCA2 are strongly induced under osteogenic conditions that elicit microcalcifications. SPCA gene expression is significantly elevated in breast cancer subtypes that are associated with microcalcifications. PMID: 28618103
3. The extract was found to comprise mainly primary fatty acid amides (PFAAs) by NMR analysis. Individual PFAAs, especially oleamide and linoleamide, almost completely inhibited hSPCA2 activity with IC50 values of 7.5 muM and 3.8 muM, respectively. PMID: 27297103
4. we found that SPCA2-transfected cells display a higher number of cells entering S phase. Altogether, our results point at the important role of SPCA2 in regulation of cell cycle in cancer cells PMID: 27316461
5. Orai1-mediated Ca(2+)-influx and SPCA2-mediated Ca(2+) uptake activity into the Golgi/secretory pathway might be coupled possibly in a microdomain. This channel/pump complex may efficiently transfer Ca(2+) into the secretory pathway, which might play a role in SPCA2-expressing secretory cells, such as mammary gland during lactation. PMID: 27692665
6. Supporting a more general neurocognition role of ATP2C2 is the previous association of ATP2C2 with attention deficit hyperactivity disorder, a condition commonly comorbid with dyslexia and language impairment. PMID: 25448322
7. Findings reveal a signaling pathway in which the Orai1-SPCA2 complex elicits constitutive store-independent Ca(2+) signaling that promotes tumorigenesis. PMID: 20887894
8. SPCA2 may have a more specialized role in mammalian cells, possibly in cellular detoxification of Mn2+ ions. PMID: 15677451
9. hSPCA2 has the ability to transport Ca(2+) and Mn(2+); both its transport and Ca(2+)- and Mn(2+)-dependent phosphoprotein intermediate formation functions are insensitive to thapsigargin inhibition PMID: 15831496
10. analysis of SPCA1 and SPCA2 isoenzymes by steady-state and transient kinetic analyses PMID: 16332677
11. ATP2C2 modulates phonological short-term memory in language impairment. PMID: 19646677
顯示更多

收起更多
亞細(xì)胞定位：

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
蛋白家族：

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIA subfamily
組織特異性：

Highly expressed in the gastrointestinal and respiratory tracts, prostate, thyroid, salivary, and mammary glands. Expressed in colon epithelial cells (at protein level). Expressed in brain and testis (at protein level).
數(shù)據(jù)庫鏈接：

HGNC: 29103

OMIM: 613082

KEGG: hsa:9914

STRING: 9606.ENSP00000262429

UniGene: Hs.6168

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human