ATP2A3 Antibody

說明書

中文名稱：

ATP2A3兔多克隆抗體
貨號：

CSB-PA088870
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA088870(ATP2A3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產(chǎn)品詳情
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靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q93084
基因名：

ATP2A3
別名：

Adenosine triphosphatase calcium antibody; AT2A3_HUMAN antibody; Atp2a3 antibody; ATPase Ca(2+) transporting ubiquitous antibody; ATPase Ca++ transporting ubiquitous antibody; Calcium pump 3 antibody; Calcium translocating P type ATPase antibody; Sarco/endoplasmic reticulum Ca2+ ATPase antibody; Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 antibody; SERCA 3 antibody; SERCA3 antibody; SERCA3b antibody; SR Ca(2+) ATPase 3 antibody; SR Ca(2+)-ATPase 3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human ATP2A3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
基因功能參考文獻：
1. Sp1, Sp3, and Klf-4 transcription factors bind to ATP2A3 proximal promoter elements and regulate basal gene expression. The study showed that these factors participated in the increase of ATP2A3 expression during cancer cell differentiation. PMID: 27433831
2. Together, these data provide evidence for the interaction of Bcl-2 with SERCA3b in vitro and in cell culture, and for Bcl-2-dependent conformational and functional changes of SERCA3b. PMID: 27639965
3. ATP2A3 methylation was not altered between patients with type 2 diabetes and healthy men. Moreover, a glucose challenge did not alter ATP2A3 methylation. PMID: 28011458
4. we make a comprehensive analysis of the current knowledge of the role of the SERCA pumps in the pathophysiology of insulin-dependent diabetes mellitus type 1 (TIDM) and type 2 (T2DM) in the heart and beta-cells in the pancreas PMID: 25270119
5. Normal choroid plexus epithelial cells express SERCA3 abundantly, SERCA3 expression is strongly decreased in papillomas, and is absent in choroid plexus carcinoma, while expression in hyperplastic epithelium is high, similarly to normal epithelium. PMID: 24224513
6. aberrant SERCA3 expression is closely linked to the adenoma-adenocarcinoma sequence and progression of colorectal carcinomas. PMID: 24213720
7. The Ca2+-ATPase activity in cloned Plasmodiuim falciparum strain D6 protein is higher than in cloned strain W2 protein. The Ca2+-ATPase activity in isolates from malaria patients varied widely. PMID: 23235306
8. Loss of SERCA3 expression is associated with lung cancer. PMID: 23157274
9. High SERCA3 expression is associated with pathogenesis, invasion, metastasis of gastric carcinomas. PMID: 22948776
10. novel sarco/endoplasmic isoforms; data suggest that the SERCA3 gene products have a more widespread role in cellular Ca2+ signaling than previously appreciated PMID: 11956212
11. SERCA3 constitutes an interesting new differentiation marker that may prove useful for the analysis of the phenotype of gastrointestinal adenocarcinomas. PMID: 11986315
12. Results describe the catalytic cycle of three human SERCA3 isoenzymes: SERCA3a, b, and c. PMID: 12207029
13. A method is described for a calcium-activated ATPase technique to be peformed. PMID: 12503734
14. monoclonal antibody PL/IM430 inhibits SERCA3 activity by sterically preventing movement of the actuator domain into a catalytically critical position in the E2 conformation of the enzyme. PMID: 12540840
15. SERCA3 isoforms have a more widespread role in cellular Ca(2+) signaling: analysis of SERCA3f isoform PMID: 15028735
16. link SERCA3 expression to the state of differentiation of colonic epithelial cells PMID: 15972967
17. By increasing the rate of Ca2+ sequestration, up-regulation of SERCA 3 counteracts the cytosolic increase in Ca2+ concentration. PMID: 16250893
18. Data showed that overexpression of SERCA3b affected cell adhesion and SERCA3f overexpression resulted in an increase in endoplasmic reticulum stress markers. PMID: 16725111
19. Ca2+ ATPase sarcoplasmic/endoplasmic reticulum calcium ATPase 3 are involved in an increased susceptibility to develop head and neck squamous cell carcinoma in humans. PMID: 18295663
20. These findings revisit the human heart's Ca(2+)ATPase system and indicate that SERCA3f may account for the mechanism of endoplasmic reticulum stress in vivo in heart failure. PMID: 18947868
21. ATP2A3 gene is involved in cancer susceptibility. PMID: 19100511
22. two distinct SERCA3 fragmentation profiles sign the co-expression of SERCA3 proteins in two conformational states in platelet membranes. PMID: 19135027
23. affinity for Ca(2+) is inherently lower for SERCA3 expressed in situ than for other SERCA isoforms PMID: 19225163
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亞細胞定位：

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIA subfamily
組織特異性：

Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic orig
數(shù)據(jù)庫鏈接：

HGNC: 813

OMIM: 601929

KEGG: hsa:489

STRING: 9606.ENSP00000353072

UniGene: Hs.513870

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