ATG4B Antibody, Biotin conjugated
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中文名稱：ATG4B兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA002290LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ATG4B Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：APG4 autophagy 4 homolog B antibody; APG4B antibody; ATG4 autophagy related 4 homolog B (S. cerevisiae) antibody; ATG4B antibody; ATG4B_HUMAN antibody; AUT like 1 cysteine endopeptidase antibody; AUT-like 1 cysteine endopeptidase antibody; AUTL1 antibody; Autophagin 1 antibody; Autophagin-1 antibody; Autophagy related 4B cysteine peptidase antibody; Autophagy related cysteine endopeptidase 1 antibody; Autophagy related protein 4 homolog B antibody; Autophagy-related cysteine endopeptidase 1 antibody; Autophagy-related protein 4 homolog B antibody; Cysteine protease ATG4B antibody; hAPG4B antibody; MGC1353 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Cysteine protease ATG4B protein (350-400AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
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基因功能參考文獻：
- ATG4B expression was observed markedly upregulated by EWS-FLI1 overexpression, and silencing of ATG4B dramatically inhibits autophagy in Ewing sarcoma cells. PMID: 28902354
- study demonstrates that Rab7b regulates LC3 processing by modulating Atg4B activity; taken together, findings reveal Rab7b as a novel negative regulator of autophagy through its interaction with Atg4B PMID: 28835545
- ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 PMID: 28287329
- O-GlcNAcylation of ATG4B regulates autophagy activation by increasing its proteolytic activity under metabolic stress condition PMID: 27527864
- these results demonstrate a novel association of ATG4B positive expression with HER2 positive breast cancers PMID: 27556700
- Knockdown of ATG4B had only a minor effect on AMPK activation and G1 phase arrest in liver kinase B1-deficient or AMPK-inhibited cancer cells. PMID: 29169176
- Our work describes an MST4-ATG4B signaling axis that influences glioblastoma autophagy and malignancy PMID: 29232556
- Data show that ULK1, a protein kinase activated at the autophagosome formation site, phosphorylates human ATG4B on serine 316. PMID: 28821708
- Reporter assay showed that HSF1 increased the transcriptional activity of ATG4B gene promoter, and chromatin immunoprecipitation assay verified that HSF1 bound to the site (-1429 to -1417) in ATG4B gene promoter region. PMID: 28889000
- The structure and regulatory machinery of Atg4b [review] PMID: 28253956
- MIRlet-7i is able to regulate autophagic activity via regulating Atg4B expression, which might contribute to the pathogenesis of pre-eclampsia. PMID: 27770612
- Results demonstrated that upregulation of miR-34a by transfection or demethylation resulted in the enhanced apoptosis and drug sensitivity in prostate cancer cells. ATG4B, directly regulated by miR-34a through AMPK/mTOR, was involved in this process. PMID: 26499184
- Purified ATG4B protein interact with LC3B in vitro. PMID: 25652856
- ATG4B independently plays a role as a positive regulator on tumor proliferation and a negative regulator on autophagy in colorectal cancer cells. PMID: 24991826
- This study identifies ATG4B as a potential biomarker for predicting therapeutic response in treatment-naive chronic myeloid leukemia stem/progenitor cells and uncovers ATG4B as a possible drug target in these cells. PMID: 24755409
- The actions of ATG4 family members (particularly ATG4B) are required for the control of autophagosome fusion with late, degradative compartments in differentiating human erythroblasts. PMID: 23508006
- HsAtg4B negatively regulates the localization of LC3 to a membrane compartment by delipidation PMID: 15187094
- analysis of specificity and catalysis of HsAtg4B PMID: 16183633
- crystal structure of human Atg4b by X-ray crystallography at 2.0 A resolution, and show that Atg4b is a cysteine protease whose active catalytic triad site consists of Cys74, His280 and Asp278 PMID: 16325851
- Murine Atg8L/Apg8L modification is mediated by human Atg4B. PMID: 16704426
- The crystal structures of catalytically inert human Atg4B in complex with processed and unprocessed forms of LC3 showed that, on LC3 binding, the regulatory loop and the N-terminal tail of HsAtg4B undergo large conformational changes. PMID: 19322194
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亞細胞定位：Cytoplasm.
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蛋白家族：Peptidase C54 family
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