ASIP Antibody

文獻引用 (1) 說明書

中文名稱：

ASIP兔多克隆抗體
貨號：

CSB-PA002212LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA002212LA01HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA002212LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ASIP Polyclonal antibody
Uniprot No.：

P42127
基因名：

ASIP
別名：

ASIP antibody; AGTI antibody; AGTIL antibody; ASP antibody; Agouti-signaling protein antibody; ASP antibody; Agouti switch protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Agouti-signaling protein (23-112AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ASIP Antibody (CSB-PA002212LA01HU)，的標記方式是Non-conjugated。對于ASIP Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA002212LB01HU	ASIP Antibody, HRP conjugated	ELISA
FITC	CSB-PA002212LC01HU	ASIP Antibody, FITC conjugated
Biotin	CSB-PA002212LD01HU	ASIP Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Agouti Signaling Protein and Its Receptors as Potential Molecular Markers for Intramuscular and Body Fat Deposition in Cattle Liu Y,Frontiers in physiology,2023

產品評價

靶點詳情

功能：

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
基因功能參考文獻：
1. ASIP expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
2. Polymorphisms of ASIP were found to be associated with skin, hair, and eye color in a phenotypically diverse Brazilian population. More research is needed to determine its usefulness in forensic science. PMID: 25801600
3. ASIP gene mutation is involved in the development of facial pigmented lesions. PMID: 25705849
4. Data show that ASIP TG/TG diplotype, which is known to be associated with melanoma risk, was linked to a 5-fold increase in hazard of death from melanoma. PMID: 25382380
5. An increased risk of melanoma (odds ratio [OR] 1.27, 95% confidence interval [95% CI] 1.03-1.57) in carriers of the rs4911414 variant, located 120 kb upstream of ASIP. PMID: 22628150
6. By using a population-based material of high-risk melanoma cases, we demonstrate a significant effect of both MC1R red hair color (RHC) variants and an ASIP haplotype, but could not replicate an association with postulated risk SNPs of TYR and TYRP1. PMID: 22447455
7. Findings suggest that ASIP locus is associated with a number of non-melanoma skin cancers. PMID: 21221757
8. Further analysis of binding and functional data suggests that the ASIP C-terminal loop (a six-amino-acid segment closed by the final disulfide bond) is essential for high-affinity MC1R binding and inverse agonism. PMID: 20831872
9. polymorphism in the agouti signaling protein gene is associated with human pigmentation PMID: 11833005
10. results show that men and women of similar age and BMI present similar agouti signal protein mRNA levels in omental and subcutaneous abdominal adipocytes but a sexual dimorphism exists in the relationship between its expression and BMI PMID: 12055320
11. Results identify five genes that are down-regulated by agouti signalling protein (ASIP), indicating a likely role for ASIP in human melanogenesis. PMID: 12519127
12. Agouti mRNA levels significantly elevated in type 2 diabetes. Insulin did not regulate agouti mRNA. Agouti can regulate adipogenesis.There are functional consequences of elevated agouti levels in human adipose tissue. PMID: 14633851
13. Our study suggests that the ASIP G>A polymorphism exhibits a dominant effect leading to lighter skin color and that variation in the ASIP gene may have been one of several factors contributing to reductions in pigmentation in some populations. PMID: 15726415
14. ASIP polymorphism was not associated with pigmentation, nevi, or melanoma risk PMID: 15998953
15. An important role for exon 17b of ASIP in cancer cells was identified;alternative splicing isoforms ,hASIP-sa, hASIP-sb, had different effects on cell growth and Fas/FasL-mediated apoptosis in BEL-7404 human hepatoma cells. PMID: 16091846
16. A/G polymorphism in the 3'-UTR region of the agouti signaling protein contributes to dark pigmentation. PMID: 16704456
17. Cocaine- and amphetamine-regulated transcript protein is colocalized with this protein and neuropeptide Y in human hypothalamus. PMID: 17525122
18. ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma. PMID: 18488027
19. Two coding variants in TPCN2 are associated with hair color, and a variant at the ASIP locus shows strong association with skin sensitivity to sun, freckling and red hair. PMID: 18488028
20. ASIP polymorphism was found not to be associated with skin malignant melanoma or basal cell carcinoma. PMID: 18637131
21. Polymorphism of pigmentation genes (OCA2 and ASIP) in some populations of Russia PMID: 19382693
22. Single nucleotide polymorphisms in ASIP is associated with basal cell carcinoma PMID: 19384953
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亞細胞定位：

Secreted.
組織特異性：

Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
數據庫鏈接：

HGNC: 745

OMIM: 600201

KEGG: hsa:434

STRING: 9606.ENSP00000364092

UniGene: Hs.659995

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