ASH1L Antibody

中文名稱：

ASH1L兔多克隆抗體
貨號：

CSB-PA865114LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human glioma using CSB-PA865114LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA865114LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA865114LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ASH1L Polyclonal antibody
Uniprot No.：

Q9NR48
基因名：

ASH1L
別名：

Absent small and homeotic disks protein 1 homolog antibody; Absent Small or Homeotic Like antibody; Absent Small or Homeotic Like antibody; ASH 1 antibody; ASH 1L antibody; ash1 (absent small or homeotic 1) antibody; Ash1 (absent small or homeotic) like antibody; ASH1-like protein antibody; ASH1L antibody; ASH1L_HUMAN antibody; ASH1L1 antibody; FLJ10504 antibody; huASH1 antibody; KIAA1420 antibody; KMT2H / ASH1 antibody; Lysine N-methyltransferase 2H antibody; Probable histone-lysine N-methyltransferase ASH1L antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Histone-lysine N-methyltransferase ASH1L protein (1906-2160AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ASH1L Antibody (CSB-PA865114LA01HU)，的標記方式是Non-conjugated。對于ASH1L Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA865114LB01HU	ASH1L Antibody, HRP conjugated	ELISA
FITC	CSB-PA865114LC01HU	ASH1L Antibody, FITC conjugated
Biotin	CSB-PA865114LD01HU	ASH1L Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear.
基因功能參考文獻：
1. DDB2 promotes cyclobutane pyrimidine dimer excision by recruiting the histone methyltransferase ASH1L, which methylates lysine 4 of histone H3. In turn, methylated H3 facilitates the docking of the XPC complex to nucleosomal histone octamers. PMID: 29109511
2. suppresses matrix metalloproteinase through mitogen-activated protein kinase signaling pathway in pulpitis PMID: 28041684
3. There has been increasing evidence that heterozygous mutation of ASH1L is associated with ID and autism spectrum disorders. We suggest that ASH1L abnormalities may cause a novel MCA/ID syndrome. PMID: 28394464
4. Epigenetic regulators play vital roles in cancer pathogenesis and represent a new frontier in therapeutic targeting. Our studies provide basic mechanistic insight into the role of H3K36me2 in transcription activation and MLL leukemia pathogenesis and implicate ASH1L histone methyltransferase as a promising target for novel molecular therapy. PMID: 27154821
5. Our data suggest a role for ASH1L, a methyl transferase protein and member of the trithorax (Trx) family, in regulation of the HBB gene and as a potential modifier of beta-thalassaemia severity. PMID: 27434206
6. Structural features were identified in ASH1L related to its' function and enzymatic activity. PMID: 26292256
7. Both ASH1L and SETD2 are H3K36 specific methyltransferases but only SETD2 can trimethylate this mark. PMID: 26002201
8. These data demonstrate that miR-142-3p downregulation has a role in thyroid tumorigenesis, by regulating ASH1L and MLL1. PMID: 25238203
9. Our results uncover a novel regulatory cascade orchestrated by Ash1l with RAR and provide insights into mechanisms underlying the establishment of the transcriptional activation that counteracts Polycomb silencing PMID: 24244179
10. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-Set7 were not affected by ubH2A. PMID: 24019522
11. induction of Cdk5 activity is a novel mechanism through which hASH1 may regulate migration in lung carcinogenesis PMID: 22696682
12. Long Non-coding RNA, DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription. PMID: 22541069
13. ASH1 and MLL1 synergize in activation of Hox genes. PMID: 22140534
14. human ASH1L specifically methylates histone H3 Lys-36. PMID: 21239497
15. These data suggest that ASH1L occupies most, if not all, active genes and methylates histone H3 in a nonredundant fashion at a subset of genes. PMID: 17923682
顯示更多

收起更多
亞細胞定位：

Nucleus. Cell junction, tight junction. Chromosome.
蛋白家族：

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily
組織特異性：

Widely expressed, with highest level in brain, heart and kidney.
數據庫鏈接：

HGNC: 19088

OMIM: 607999

KEGG: hsa:55870

STRING: 9606.ENSP00000376204

UniGene: Hs.491060

Most popular with customers

YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
VIM Recombinant Monoclonal Antibody

Applications: ELISA, IHC, IF

Species Reactivity: Human
VDR Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human