ASCL2 Antibody
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中文名稱：ASCL2兔多克隆抗體
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貨號：CSB-PA966616
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規格：￥2024
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圖片：
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Western blot analysis of extracts from K562 cells, using ASCL2 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ASCL2 Polyclonal antibody
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Uniprot No.：
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基因名：ASCL2
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from Internal of Human ASCL2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
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基因功能參考文獻：
- this study shows that Ascl2 level was higher in peripheral blood mononuclear cells from Sjogren's syndrome patients compared with those from healthy controls PMID: 28728856
- A novel HIF-1alpha/Ascl2/miR-200b regulatory feedback circuit in modulating EMT-MET plasticity of CRC cells, which could serve as a possible therapeutic target. PMID: 28899657
- WiNTRLINC1 interacts with TCF4/beta-catenin to mediate the juxtaposition of its promoter with the regulatory regions of ASCL2. PMID: 27292638
- Ascl2 over-expression is associated with colorectal neoplasms. PMID: 26307678
- expression of ASCL2 may identify an aggressive subgroup in lung squamous cell carcinoma PMID: 26483561
- SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis. PMID: 25866254
- SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. PMID: 25277775
- ASCL2 gene expression is regulated by miR-200a/b/c, miR-141 and miR429 levels in colon cancer. PMID: 25371200
- Ascl2 directly initiates follicular T-helper cell development PMID: 24463518
- These results suggest that ASCL2 might play an important role in gastric tumor growth and chemoresistance. PMID: 23181270
- Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells PMID: 22384170
- a stem cell specific transcription signature promoted by ASCL2 has been identified to be upregulated in a subset of liver metastases, those characterised by an 11p15.5 gain PMID: 20479215
- These findings suggest that increased protein levels and DNA binding of USF1 and USF2 mediate the inhibitory effects of hypoxia and of Mash-2 on CYP19 gene expression in human placenta PMID: 12917334
- These results suggest that PACE4 expression is down-regulated by Hash-2/Mash-2 in both human and rat placenta and that many bioactive proteins might be regulated by PACE4 activity. PMID: 14561729
- ascl2 is a putative regulator of proliferation that is overexpressed in intestinal neoplasia PMID: 16568095
- Negative expression of HASH2 in complete hydatidiform moles (CM) but positive expression in malignant tumors suggests the presence of a specific mechanism for inactivation of the HASH2 gene in CM and reactivation in invasive moles or choriocarcinoma PMID: 17165436
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亞細胞定位：Nucleus.
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組織特異性：Expressed specifically in the extravillous trophoblasts of the developing placenta.
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數據庫鏈接：
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